Results 251 to 260 of about 5,109,346 (334)

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Primary and metastatic cellular landscapes in human pancreatic cancer. [PDF]

iScience
Steele NG, Sirihorachai VR, Elhossiny AM, Loveless IM, Kadiyala P, Bonilla M, Lasse-Opsahl EL, Vargas CS, Donahue KL, Kemp SB, Gunchick V, Shah YM, Frankel TL, Bednar F, Rao A, Allen BL, Shi J, Sahai V, Crawford HC, Carpenter ES, Pasca di Magliano M.   +20 more
europepmc   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Early Detection of Pancreatic Cancer: Current Advances and Future Opportunities. [PDF]

Biomedicines
Lin Z, Adeniran EA, Cai Y, Qureshi TA, Li D, Gong J, Li J, Pandol SJ, Jiang Y.   +8 more
europepmc   +1 more source

Pancreatic Cancer Cell DNA Content Correlates With Long-term Survival After Pancreatoduodenectomy

, 1991
David C. Allison, Kallol Bose, Ralph H. Hruban, Steven Piantadosi, William C. Dooley, John K. Boitnott, John L. Cameron   +6 more
openalex   +2 more sources

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer. [PDF]

Biomedicines
Tsukagoshi M, Araki K, Kubo N, Igarashi T, Kawai S, Hagiwara K, Hoshino K, Seki T, Okuyama T, Fukushima R, Shoda T, Shirabe K.   +11 more
europepmc   +1 more source

Morbidity and Mortality After Radical and Palliative Pancreatic Cancer Surgery Risk Factors Influencing the Short-Term Results

, 1993
K Bakkevold, B Kambestad
openalex   +2 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source