Results 251 to 260 of about 5,871,156 (346)

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Cancer Discovery, 2018
S. Pushalkar, Mautin Hundeyin, Donnele Daley, C. Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana Torres, G. Werba, Kevin J. Zhang, Yuqi Guo, Qianhao Li, Neha Akkad, Sarah Lall, Benjamin J. Wadowski, Johana Gutierrez, Juan Kochen Rossi, Jeremy W. Herzog, B. Diskin, Alejandro Torres‐Hernandez, J. Leinwand, Wei Wang, Pardeep S. Taunk, Shivraj Savadkar, M. Janal, A. Saxena, Xin Li, D. Cohen, R. B. Sartor, D. Saxena, G. Miller   +32 more
semanticscholar   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Cystic lesions and their role in pancreatic cancer risk stratification. [PDF]

Transl Oncol
Lyons R, Maher SG, Lysaght J.
europepmc   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer. [PDF]

J Natl Cancer Inst
Williams D, Patel C, Murray K, Oldfield L, Small B, Barrera LN, O'Sullivan R, Birch-Ford J, Evans A, Campbell F, Perez-Mancera PA, Halloran CM, Palmer D, Greenhalf W, Copple IM, Goldring C, Hackert T, Jackson R, Neoptolemos JP, Springfeld C, Büchler MW, Michalski CW, Ghaneh P, Costello E.   +23 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective. [PDF]

Biology (Basel)
Li X, Lyu H, Wu Y, Chen A, Wu G, Zhang R, Xiao S, Guo D, Zhang Q, Yan C, Tang J, Zhou C.   +11 more
europepmc   +1 more source

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Nature Cell Biology, 2015
B. Costa-Silva, Nicole M. Aiello, A. Ocean, Swarnima Singh, Haiying Zhang, B. K. Thakur, A. Becker, Ayuko Hoshino, M. T. Mark, H. Molina, J. Xiang, Tuo Zhang, T. Theilen, G. García‐Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, G. Rodrigues, Tang-Long Shen, K. Labori, I. Lothe, E. Kure, Jonathan M. Hernandez, A. Doussot, Saya H. Ebbesen, P. Grandgenett, M. Hollingsworth, Maneesh Jain, K. Mallya, S. Batra, W. Jarnagin, R. Schwartz, Irina R Matei, H. Peinado, B. Stanger, J. Bromberg, D. Lyden   +36 more
semanticscholar   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source