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The Biomedical & Life Sciences Collection, 2004
Pancreatic cancer remains a major unsolved health problem, with conventional cancer treatments having little impact on disease course. Almost all patients who have pancreatic cancer develop metastases and die. The main risk factors are smoking, age, and some genetic disorders, although the primary causes are poorly understood.
Donghui, Li +3 more
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Pancreatic cancer remains a major unsolved health problem, with conventional cancer treatments having little impact on disease course. Almost all patients who have pancreatic cancer develop metastases and die. The main risk factors are smoking, age, and some genetic disorders, although the primary causes are poorly understood.
Donghui, Li +3 more
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Pancreatitis and Pancreatic Cancer
Primary Care: Clinics in Office Practice, 2017Most cases of acute pancreatitis are related to gallstones. More than 80% resolve within a few days. The diagnosis is based on upper abdominal pain, elevated lipase and/or amylase, and transabdominal ultrasound findings. Management requires early aggressive hydration, pain control, nutritional support, and monitoring for progression.
Robert Freelove, Anne Walling
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Current Opinion in Oncology, 1998
Despite the many advances reported during the past year, pancreatic cancer remains a profound therapeutic challenge. Helical CT has become the preferred staging study at many institutions. The role of chemoradiation therapy in a preoperative and postoperative setting is being defined. Gemcitabine has become first-line therapy for patients with advanced
Randall E. Brand, Margaret A. Tempero
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Despite the many advances reported during the past year, pancreatic cancer remains a profound therapeutic challenge. Helical CT has become the preferred staging study at many institutions. The role of chemoradiation therapy in a preoperative and postoperative setting is being defined. Gemcitabine has become first-line therapy for patients with advanced
Randall E. Brand, Margaret A. Tempero
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Pancreatitis and the Risk of Pancreatic Cancer
Pancreas, 1995To offer quantitative evidence on the association between pancreatitis and pancreatic cancer, we analyzed data from a hospital-based case-control study conducted in northern Italy between 1983 and 1992, including a total of 362 incident cases of histologically confirmed pancreatic cancer and 1,408 controls admitted to hospital for acute, nonneoplastic,
E. Fernandez +5 more
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Current Treatment Options in Oncology, 2000
Optimal therapy for pancreatic adenocarcinoma requires surgical removal with tumor-free margins. Superior outcomes have been reported for high-volume centers incorporating a multidisciplinary approach. Postoperative ("adjuvant") chemotherapy and radiation should be considered in patients with successfully resected primary tumors.
Wayne H. Pinover +3 more
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Optimal therapy for pancreatic adenocarcinoma requires surgical removal with tumor-free margins. Superior outcomes have been reported for high-volume centers incorporating a multidisciplinary approach. Postoperative ("adjuvant") chemotherapy and radiation should be considered in patients with successfully resected primary tumors.
Wayne H. Pinover +3 more
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Pancreatitis as a risk for pancreatic cancer
Gastroenterology Clinics of North America, 2002Chronic pancreatitis clearly predisposes to pancreatic cancer, with early onset-long duration chronic pancreatitis from cystic fibrosis, TP, and HP conferring the highest risk. Chronic pancreatitis is not a critical step, however, but rather one of several conditions that accelerate the accumulation of critical genetic mutations and chromosomal losses ...
Katherine L. Pogue-Geile +1 more
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Chronic Pancreatitis and Pancreatic Cancer
New England Journal of Medicine, 1993Pancreatic cancer is the 5th leading cause of death from cancer and the 11th most common cancer in the United States1; each year 24,000 people die of pancreatic cancer in this country. The incidence of pancreatic cancer increased dramatically several decades ago, but it has remained fairly stable over the past 15 years (9.1 per 100,000).
John L. Cameron, Ellen B. Gold
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Chronic Pancreatitis and Pancreatic Cancer
Digestive Diseases, 2002Pancreatic cancer is the fourth leading cause of cancer deaths in the USA in both sexes. Early diagnosis is difficult and the overall mortality rate is high. Individuals at high risk for pancreatic cancer include smokers, and persons with all forms of chronic alcoholic, metabolic, tropical or hereditary pancreatitis.
Albert B. Lowenfels, Patrick Maisonneuve
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Nature reviews: Gastroenterology & hepatology, 2023
T. F. Stoop +14 more
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T. F. Stoop +14 more
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Pancreatic Resection for Pancreatic Cancer
Surgical Clinics of North America, 1989In the majority of patients, pancreatic resection is performed for a proved carcinoma or for a mass in the pancreas with clinical features of carcinoma. Preoperative preparation is similar to that for other cancer operations, and good nutritional status and normal clotting factors are important.
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