Results 221 to 230 of about 646,520 (340)

Severe Respiratory and Swallowing Disorders in Infantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease Type 1: Two Cases. [PDF]

Neurol Genet
Berling E, Latour P, Loiselet K, Guémy C, Vidoni L, Romero NB, Lacene E, Evangelista T, Stojkovic T.   +8 more
europepmc   +1 more source

Underlying Disease Stress Augments Plasma and Tissue Adrenomedullin (AM) Responses to Endotoxin: Colocalized Increases in AM and Inducible Nitric Oxide Synthase within Pancreatic Islets [PDF]

, 1999
Ted H. Elsasser
openalex   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

An infectious pancreatic necrosis virus isolated from common dab Limanda limanda previously affected with X-cell disease, a disease apparently unrelated to the presence of the virus

, 1988
A. Diamant, D. A. Smail, Leon R. McFarlane, A.P. Thomson   +3 more
openalex   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

A Novel PTRH2 Gene Mutation Causing Infantile-onset Multisystem Neurologic, Endocrine, and Pancreatic Disease in a Bahraini Patient. [PDF]

Oman Med J
Isa HM, Khalaf SD, Janahi S, Naser MM, Al Hamad N, Alhaddar H, Busehail M.   +6 more
europepmc   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Pancreatic involvement in von Hippel–Lindau disease [PDF]

, 2000
Pascal Hammel, Valérie Vilgrain, Benoı̂t Terris, A. Penfornis, Alain Sauvanet, Jean-Michel Corréas, Dominique Chauveau, Axel Balian, Catherine Beigelman‐Aubry, Dermot O’Toole, P Bernadès, Philippe Ruszniewski, Richard J. Kahnoski   +12 more
openalex   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

The Gut Microbiome in Pancreatic Disease. [PDF]

Clin Gastroenterol Hepatol, 2019
Akshintala VS, Talukdar R, Singh VK, Goggins M.   +3 more
europepmc   +1 more source