Results 251 to 260 of about 10,302,641 (371)
Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li +9 morewiley +1 more sourceABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium.
Oncology Report, 2013 C. Rizzato, D. Campa, R. Pezzilli, P. Souček, W. Greenhalf, G. Capurso, R. Talar-Wojnarowska, A. Heller, K. Jamroziak, K. Khaw, T. Key, F. Bambi, S. Landi, B. Mohelníková‐Duchoňová, L. Vodickova, M. Büchler, P. Bugert, P. Vodicka, J. Neoptolemos, J. Werner, J. Hoheisel, Andrea S Bauer, N. Giese, F. Canzian +23 moresemanticscholar +1 more sourceExendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease [PDF]
, 2008 Bronwen Martin, Erin Golden, Olga D. Carlson, Paul J. Pistell, Jie Zhou, Wook Kim, Brittany P. Frank, Sam Thomas, Wayne Chadwick, Nigel H. Greig, Gillian P. Bates, Kirupa Sathasivam, Michel Bernier, Stuart Maudsley, Mark P. Mattson, Josephine M. Egan +15 moreopenalex +1 more sourceSupplemental Figures and Table 1 from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
, 2023 Stephen J. Murphy, Steven N. Hart, Geoffrey C. Halling, Sarah H. Johnson, James B. Smadbeck, Travis Drucker, Joema Felipe Lima, Fariborz Rakhshan Rohakhtar, Faye R. Harris, Farhad Kosari, Subbaya Subramanian, Gloria M. Petersen, Timothy D. Wiltshire, Benjamin R. Kipp, Mark J. Truty, Robert R. McWilliams, Fergus J. Couch, George Vasmatzis +17 moreopenalex +2 more sourcesTriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy
Advanced Science, EarlyView.We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su +9 morewiley +1 more sourceStellate cells are in utero markers of pancreatic disease in cystic fibrosis. [PDF]
Mol MedLeir SH, Tkachenko S, Paranjapye A, Meckler F, Van Wettere AJ, Kerschner JL, Kuznetsov E, Schacht M, Gillurkar P, Regouski M, Viotti Perisse I, Marriott CM, Liu Y, Bunderson I, White KL, Polejaeva IA, Harris A. +16 moreeuropepmc +1 more sourcePatterns of Disease Dissemination and Survival in Patients with Synchronous and Metachronous Metastatic Pancreatic Adenocarcinoma: Nationwide Population-Based Study
Merlijn U.J.E. Graus, Aniek E. van Diepen, Kim Josemanders, Marc G. Besselink, Stefan A.W. Bouwense, Lois A. Daamen, Ignace H. J. T. de Hingh, Evelien J.M. de Jong, Hanneke W.M. van Laarhoven, Vincent E. de Meijer, I. Quintus Molenaar, Martijn W.J. Stommel, Liselot Valkenburg‐van Iersel, Hanneke Wilmink, Lydia G. van der Geest, Judith de Vos‐Geelen +15 moreopenalex +1 more sourceSupplementary Figure S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
, 2023 Sontoria D. King, Swathi Veliginti, Martijn C.G.J. Brouwers, Zhewen Ren, Wei Zheng, Veronica Wendy Setiawan, Lynne R. Wilkens, Xiao‐Ou Shu, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Federico Canzian, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Christopher A. Haiman, Manolis Kogevinas, Charles Kooperberg, Loı̈c Le Marchand, Rachel Ε. Neale, Kala Visvanathan, Emily White, Demetrius Albanes, Gabriella Andreotti, Ana Babić, Sonja I. Berndt, Lauren K. Brais, Paul Brennan, Julie E. Buring, Kari G. Rabe, William R. Bamlet, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Edward L. Giovannucci, Thilo Hackert, Manal M. Hassan, Verena Katzke, Robert C. Kurtz, I‐Min Lee, Núria Malats, Neil Murphy, Ann L. Oberg, Irene Orlow, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jean Wactawski‐Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch‐Jacquotte, Kai Yu, Brian M. Wolpin, Eric J. Duell, Donghui Li, Rayjean J. Hung, Sandra Pérdomo, Marjorie L. McCullough, Neal D. Freedman, Alpa V. Patel, Ulrike Peters, Elio Ríboli, Malin Sund, Anne Tjønneland, Jun Zhong, Stephen K. Van Den Eeden, Peter Kraft, Harvey A. Risch, Laufey T. Ámundadóttir, Alison P. Klein, Rachael Z. Stolzenberg‐Solomon, Samuel O. Antwi +76 moreopenalex +1 more sourceMetabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer
Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen +11 morewiley +1 more source
