Results 271 to 280 of about 646,520 (340)

CYTOKINES AND DISTRIBUTION OF IMMUNE CELLS IN PATIENTS WITH SURGICAL HEPATOBILIARY-PANCREATIC (HBP) DISEASE WITH AND WITHOUT JAUNDICE

, 1999
Mikael Ljungdahl, Johanna Österberg, U Haglund   +2 more
openalex   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature. [PDF]

Gastroenterology Res, 2016
Tariq H, Nayudu S, Akella S, Glandt M, Chilimuri S.   +4 more
europepmc   +1 more source

Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy

Advanced Science, EarlyView.
This study reveals how blocking a detox enzyme called GLO1 increases the buildup of a toxic molecule, methylglyoxal (MGO), which triggers cancer cell death by ferroptosis. A protein called PJA1 drives this process. Targeting the PJA1–GLO1 pathway boosts the effectiveness of ferroptosis‐inducing treatments in tumors, offering a promising approach for ...
Xinyue Zhang, Leng Han, Zimu Wang, Hanghui Yu, Jiao Liu, Rui Kang, Daolin Tang, Zhengjia Liu, Xianlong Du, Enyong Dai   +9 more
wiley   +1 more source

SURF: A Self‐Supervised Deep Learning Method for Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Science, EarlyView.
SURF is a robust reference‐free deconvolution tool that integrates high‐dimensional spatial transcriptomics gene expression analysis with self‐supervised deep learning, enabling effective modeling of non‐linear gene interactions and spot relationships.
Shuyu Liang, Zixia Zhou, Peng Huang, Junhu Fu, Jing Jiao, Yunxia Huang, Shichong Zhou, Guanlin Wang, Yuanyuan Wang, Yi Guo   +9 more
wiley   +1 more source

Pancreatic and hepatobiliary cancers: adjuvant therapy and management of inoperable disease

, 2000
Bengt Glimelius
openalex   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

Analysis of K-ras codon 12 point mutation in pancreatic juice and duodenal aspirate from patients with pancreatic diseases

, 2000
Terumi Kamisawa, Naoto Egawa, Nobuhiro Sakaki, Junichi Ishiwata, Toshikazu Yamaguchi   +4 more
openalex   +2 more sources

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source