Results 31 to 40 of about 9,801,285 (428)

Pancreatic stellate cell: Pandora's box for pancreatic disease biology

World Journal of Gastroenterology, 2017
Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic
Ratnakar R Bynigeri, Aparna Jakkampudi, Ramaiah Jangala, C. Subramanyam, M. Sasikala, Venkat Rao, Nageshwar Reddy, R. Talukdar, D. Reddy, G. Rao   +9 more
semanticscholar   +1 more source

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis and Treatment.

Gastroenterology, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our understanding of the biology of PDAC have revealed new opportunities ...
L. Wood, M. Canto, E. Jaffee, D. Simeone
semanticscholar   +1 more source

Cost-effectiveness of diagnostic laparoscopy for assessing resectability in pancreatic and periampullary cancer. [PDF]

, 2015
Surgical resection is the only curative treatment for pancreatic and periampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understaged by computerised tomography (CT).
Davidson, BR, Gurusamy, KS, Morris, S, Sheringham, J   +3 more
core   +1 more source

Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2021
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis.
M. Tempero, M. Malafa, M. Al-Hawary, S. Behrman, A. Benson, D. Cardin, E. Chiorean, V. Chung, B. Czito, M. Del Chiaro, M. Dillhoff, T. Donahue, E. Dotan, C. Ferrone, Christos Fountzilas, J. Hardacre, W. Hawkins, Kelsey Klute, A. Ko, J. Kunstman, N. Loconte, A. Lowy, C. Moravek, E. Nakakura, A. Narang, Jorge V. Obando, P. Polanco, S. Reddy, M. Reyngold, C. Scaife, Jeanne Shen, C. Vollmer, R. Wolff, B. Wolpin, B. Lynn, Giby V. George   +35 more
semanticscholar   +1 more source

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. [PDF]

, 2007
Pancreatic ductal adenocarcinoma (PDA) is an extremely aggressive malignancy, which carries a dismal prognosis. Activating mutations of the Kras gene are common to the vast majority of human PDA.
Biankin, Andrew V, Cano, David A, Dawson, Amanda C, Deramaudt, Therese, Dlugosz, Andrzej, Gutierrez, Pedro JA, Hebrok, Matthias, Heiser, Patrick W, Henshall, Susan M, Kench, James G, Pasca di Magliano, Marina, Rustgi, Anil K, Segara, Davendra, Sutherland, Robert L   +13 more
core   +8 more sources

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

Journal of Translational Medicine, 2023
Background LIPH, a membrane-associated phosphatidic acid-selective phospholipase A1a, can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of the plasma membrane.
Lijie Han, Yongsheng Jiang, Minmin Shi, Lina Gan, Zhichong Wu, Meilin Xue, Youwei Zhu, Cheng Xiong, Ting Wang, Xiaozhu Lin, Baiyong Shen, Lingxi Jiang, Hao Chen   +12 more
doaj   +1 more source

RETRACTED: GATA4 Regulates Inflammation-Driven Pancreatic Ductal Adenocarcinoma Progression

Frontiers in Cell and Developmental Biology, 2021
Cancer-associated inflammation is a key molecular feature in the progression of pancreatic ductal adenocarcinoma (PDAC). GATA4 is a transcription factor that participates in the regulation and normal development of several endoderm- and mesoderm-derived ...
Weiliang Jiang, Weiliang Jiang, Congying Chen, Congying Chen, Li Huang, Li Huang, Jie Shen, Jie Shen, Lijuan Yang, Lijuan Yang   +9 more
doaj   +1 more source

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice [PDF]

, 2018
Chronic graft-versus-host disease (cGVHD) is a severe complication of allogeneic haematopoietic stem cell transplantation. There is a growing understanding of cGVHD, and several effective therapies for cGVHD have been reported.
Kawakami, Yutaka, Mukai, Shin, Ogawa, Yoko, Tsubota, Kazuo, Urano, Fumihiko   +4 more
core   +3 more sources

BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

Frontiers in Pharmacology, 2020
Impaired autophagy has been shown to play a critical role in experimental and human acute pancreatitis (AP). However, the mechanism for transcriptional regulation of autophagy remains largely unknown.
Shuangjun Shen, Shuangjun Shen, Bin Li, Bin Li, Juanjuan Dai, Juanjuan Dai, Zengkai Wu, Zengkai Wu, Yan He, Yan He, Li Wen, Li Wen, Xingpeng Wang, Xingpeng Wang, Guoyong Hu, Guoyong Hu   +15 more
doaj   +1 more source