Results 41 to 50 of about 10,302,641 (371)

BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

Frontiers in Pharmacology, 2020
Impaired autophagy has been shown to play a critical role in experimental and human acute pancreatitis (AP). However, the mechanism for transcriptional regulation of autophagy remains largely unknown.
Shuangjun Shen, Shuangjun Shen, Bin Li, Bin Li, Juanjuan Dai, Juanjuan Dai, Zengkai Wu, Zengkai Wu, Yan He, Yan He, Li Wen, Li Wen, Xingpeng Wang, Xingpeng Wang, Guoyong Hu, Guoyong Hu   +15 more
doaj   +1 more source

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

Journal of Translational Medicine, 2023
Background LIPH, a membrane-associated phosphatidic acid-selective phospholipase A1a, can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of the plasma membrane.
Lijie Han, Yongsheng Jiang, Minmin Shi, Lina Gan, Zhichong Wu, Meilin Xue, Youwei Zhu, Cheng Xiong, Ting Wang, Xiaozhu Lin, Baiyong Shen, Lingxi Jiang, Hao Chen   +12 more
doaj   +1 more source

Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis. [PDF]

, 2018
BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer.
Bedford, Rudolph, Donahue, Timothy, Hines, O Joe, Hoos, William, Isacoff, William H, Rahib, Lola, Reber, Howard A, Upfill-Brown, Alexander   +7 more
core   +1 more source

Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature

Gastroenterology Research, 2016
There is an epidemic of obesity worldwide. The prevalence of obesity has doubled over the last three decades. Obesity, especially abdominal obesity is associated with insulin resistance that can lead to pancreatic steatosis and non-alcoholic fatty ...
H. Tariq, Suresh Kumar Nayudu, S. Akella, Mariela Glandt, S. Chilimuri   +4 more
semanticscholar   +1 more source

Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2021
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis.
M. Tempero, M. Malafa, M. Al-Hawary, S. Behrman, A. Benson, D. Cardin, E. Chiorean, V. Chung, B. Czito, M. Del Chiaro, M. Dillhoff, T. Donahue, E. Dotan, C. Ferrone, Christos Fountzilas, J. Hardacre, W. Hawkins, Kelsey A Klute, A. Ko, J. Kunstman, N. Loconte, A. Lowy, C. Moravek, E. Nakakura, A. Narang, Jorge V. Obando, Patricio M. Polanco, S. Reddy, M. Reyngold, C. Scaife, Jeanne Shen, C. Vollmer, R. Wolff, B. Wolpin, B. Lynn, Giby V. George   +35 more
semanticscholar   +1 more source

Preoperative plasma D-dimer independently predicts survival in patients with pancreatic ductal adenocarcinoma undergoing radical resection

World Journal of Surgical Oncology, 2021
Background Elevated plasma D-dimer levels have been reported as an unfavorable prognostic indicator in many solid tumors. However, there are limited relevant studies in pancreatic cancer patients following radical surgery, and the clinical significance ...
Haoda Chen, Fanlu Li, Siyi Zou, Junjie Xie, Jun Zhang, Xiaxing Deng, Hao Chen, Baiyong Shen   +7 more
doaj   +1 more source

Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society [PDF]

, 2009
Background: No data have previously been available regarding the current treatment of patients with pancreatic cancer (PC) in German hospitals and medical practices.
Boeck, Stefan, Bruns, Christiane J., Heinemann, Volker, Jauch, Karl-Walter, Sargent, Mirja, Schäfer, Claus, Seufferlein, Thomas   +6 more
core   +1 more source

Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities [PDF]

, 2017
OBJECTIVES: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients.
Abberbock, Judah, Alkaade, Samer, Amann, Stephen T., Anderson, Michelle A., Baillie, John, Banks, Peter A., Brand, Randall E., Conwell, Darwin L., Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini M., Lewis, Michele D., Machicado, Jorge D., Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Tang, Gong, Whitcomb, David C., Wilcox, C. Mel, Yadav, Dhiraj   +23 more
core   +2 more sources

Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability

Journal for ImmunoTherapy of Cancer, 2023
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji   +9 more
doaj   +1 more source

Are serial CA 19-9 kinetics helpful in predicting survival in patients with advanced or metastatic pancreatic cancer treated with gemcitabine and cisplatin? [PDF]

, 2003
Background: Serial kinetics of serum CA 19-9 levels have been reported to reflect response and survival in patients with pancreatic cancer undergoing surgery, radiotherapy, and chemotherapy.
Garbrecht, M., Heinemann, Volker, Helmberger, T., Lamerz, Rolf, Niebler, K., Schalhorn, A., Schermuly, M. M., Stemmler, J., Stieber, P., Stoffregen, C., Szymala, A. M., Wilkowski, R.   +11 more
core   +1 more source