Results 191 to 200 of about 118,689 (360)
Prolonged administration of antimicrobial prophylaxis might not be effective to prevent surgical site infections after distal pancreatectomy compared to intraoperative or up to 24‐h administration. Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most ...
Kenjiro Okada+8 more
wiley +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie+17 more
wiley +1 more source
Clip-assisted minor pancreatic duct cannulation to manage pancreatic duct leak [PDF]
Donatelli G+4 more
openaire +5 more sources
Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]
BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A+9 more
core +1 more source
The postoperative nutritional status of patients with familial adenomatous polyposis who underwent pancreas‐sparing total duodenectomy was better than that of patients who underwent pancreaticoduodenectomy. This study provides the first direct comparison of postoperative nutritional outcomes between patients with pancreas‐sparing total duodenectomy and
Ibuki Fujinuma+11 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam+10 more
wiley +1 more source
The effectiveness of intraperitoneal chemotherapy using paclitaxel (i.p.‐PTX) in pancreatic ductal adenocarcinoma (PDAC) patients with peritoneal dissemination remains elusive. This study indicated that the i.p.‐PTX therapy may improve survival in selected patients with PDAC, in particular those with occult peritoneal dissemination.
Tomohisa Yamamoto+33 more
wiley +1 more source
Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento+16 more
wiley +1 more source
Floating Pancreatic Duct Concrements in Chronic Pancreatitis [PDF]
M Schneider, Lux G
openalex +1 more source