Results 211 to 220 of about 118,689 (360)

Elucidating the Molecular Landscape of Cystic Kidney Disease: Old Friends, New Friends and Some Surprises

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cystic kidney diseases (CyKD) are a diverse group of disorders affecting more than 1 in 1000 individuals. Over 120 genes are implicated, primarily encoding components of the primary cilium, transcription factors, and morphogens. Prognosis varies greatly by molecular diagnosis. Causal variants are not identified in 10%–60% of individuals due to
Deborah Watson   +10 more
wiley   +1 more source

Beyond the Lung. Impact of Elexacaftor/Tezacaftor/Ivacaftor on Sinonasal Disease in Children With Cystic Fibrosis

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Elexacaftor/tezacaftor/ivacaftor (ETI) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) therapy that improves pulmonary function and chronic rhinosinusitis (CRS) in cystic fibrosis (CF) adults with at least one copy of the F508del CFTR mutation.
Margaux Petitjean   +16 more
wiley   +1 more source

Novel Quantitative Assessment Pipeline of Organoid Growth Dynamics Using Adapted Light Absorption and Surface Area Normalization Models

open access: yesAdvanced NanoBiomed Research, EarlyView.
Integration of ellipsoid‐derived surface area calculations, the Beer–Lambert law for light absorption, and modified darkness metrics provide a more accurate and biologically coherent framework for quantifying organoid growth kinetics, shedding dynamics, and viability.
Woojin Yang   +4 more
wiley   +1 more source

Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer

open access: yesJGH Open, Volume 7, Issue 1, Page 30-39, January 2023., 2023
This systematic review aims to evaluate the current literature involving pancreatic cancer patient groups in search of highly accurate exosomal biomarkers. We reviewed 9 studies which involved 565 participants (331 PC and 234 controls). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, and ODC1) and GPC1 reported the highest performing ...
Menazir Sha   +5 more
wiley   +1 more source

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