Results 221 to 230 of about 850,997 (356)

Ultrasound‐Triggered Release of Anticancer Nanoparticles from Electrospun Fabrics Integrated with Soft Robotic Tentacles

open access: yesAdvanced NanoBiomed Research, EarlyView.
Early pancreatic cancer detection remains challenging, causing poor treatment outcomes. This article introduces an innovative, ultrasound (US)‐triggered localized drug delivery system using gelatin nanoparticles embedded in electrospun fabric and integrated with magnetic tentacle robotics.
Samuel C. T. Moorcroft   +6 more
wiley   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

open access: yesAngewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry   +13 more
wiley   +1 more source

Revisiting Clonal Evolution Through the Light of Retrotransposons

open access: yesBioEssays, EarlyView.
We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux   +3 more
wiley   +1 more source

Precise gene analysis of Pancreatic ductal carcinoma derived from IPMN and concomitant with IPMN using resected tissue and pancreatic exocrine secretions

open access: bronze, 2018
Shinichi Takano   +11 more
openalex   +2 more sources

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

open access: yesClinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

open access: yesCancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou   +6 more
wiley   +1 more source

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