mRNA expression profiling and pathway analysis of chronic intermittent hypoxia–induced pancreatic injury in ob/ob mice [PDF]
Frontiers in PhysiologyBackgroundIncreasing evidence suggests that messenger RNA (mRNA) is centrally involved in the initiation and progression of various diseases. However, its involvement in pancreatic injury resulting from obstructive sleep apnea (OSA) continues to be ...
Yaopeng Guo +5 more
doaj +2 more sources
Clinical characteristics and long-term outcomes following pancreatic injury – An international multicenter cohort study [PDF]
Heliyon, 2023 Background: Trauma to the pancreas is rare but associated with significant morbidity. Currently available management guidelines are based on low-quality evidence and data on long-term outcomes is lacking.
Laura L. Meijer +21 more
doaj +2 more sources
Pancreatic stone protein inhibits pyroptosis of pancreatic acinar cells in sepsis-associated pancreatic injury [PDF]
Frontiers in MedicineIntroductionSepsis-associated pancreatic injury (SPI) is characterized by an increased incidence and significantly higher mortality rates. However, its underlying pathogenesis remains inadequately understood.
Pingping Liu +4 more
doaj +2 more sources
Usefulness of Endoscopic Retrograde Cholangiopancreatography in the Diagnosis and Treatment of Traumatic Pancreatic Injury in Children [PDF]
Diagnostics, 2023 Pediatric trauma patients are increasing, and trauma is the leading cause of death in children. Pancreatic injury is known as the fourth most common solid organ injury, but the diagnosis of pancreatic injury is often delayed due to the retroperitoneal ...
Seong Chan Gong +3 more
doaj +2 more sources
Pancreatic injury following immune checkpoint inhibitors: A systematic review and meta-analysis [PDF]
Frontiers in Pharmacology, 2022 Background: Pancreatic injury (pancreatitis, amylase/lipase elevation) is a rare adverse event of immune checkpoint inhibitors (ICIs). With the high number of clinical studies on ICIs, the incidence and characteristics of associated pancreatic injury (PI)
Tian Zhang +6 more
doaj +2 more sources
Risk factors and long-term prognostic impact of immune related pancreatic injury in patients receiving immune checkpoint inhibitors [PDF]
Frontiers in ImmunologyBackgroundWith the widespread use of immune checkpoint inhibitors (ICIs), the management of immune-related adverse events (irAEs) has become increasingly important.
Yu Akazawa +7 more
doaj +2 more sources
Pancreatic Injury in Severe SARS-CoV-2 Infection: A Retrospective Study Across Three Pandemic Waves [PDF]
LifeAcute pancreatitis (AP) has emerged as a notable complication in patients with COVID-19, yet the interplay between viral infection, systemic inflammation, and pancreatic injury remains incompletely understood.
Mihai Lazar +2 more
doaj +2 more sources
Investigating Immune Checkpoint Inhibitor-Induced Pancreatic Injury: When to Discontinue Cancer Therapy [PDF]
MetabolitesBackground/Objectives: The increasing use of immune checkpoint inhibitors (ICIs) in cancer treatment has led to a rise in immune-related adverse events (irAEs), including pancreatic injury.
Enrico Celestino Nista +8 more
doaj +2 more sources
Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH [PDF]
Frontiers in PharmacologyBackground and aimMetabolic-associated steatohepatitis (MASH) and pancreatic inflammation are key complications of obesity-related metabolic syndrome. Elevated IL-6; a proinflammatory cytokine, contributes to liver steatosis and pancreatic β-islet cells ...
Johnny Amer +6 more
doaj +2 more sources
Sequencing and bioinformatics analysis of exosome-derived miRNAs in mouse models of pancreatic injury induced by OSA [PDF]
Frontiers in PhysiologyIntroductionThe role of exosomal miRNAs involved in the pathogenesis and development of pancreatic injury caused by obstructive sleep apnea (OSA) remains unclear.
Jiuhuang Lan +7 more
doaj +2 more sources