Results 151 to 160 of about 1,102,866 (400)

A 'One Step' or 'Step-up' Approach for Infected Pancreatic Necrosis – Which is More Suitable for a Developing Country?

, 2022
Amitabh Yadav, Samiran Nundy
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Features of Ultrasonographic Anatomy and Manifestations of Local Complications in Acute Necrotizing Pancreatitis

Инновационная медицина Кубани
Relevance: Diagnosing pancreatic necrosis and its complications is challenging despite the widespread use of state-of-the-art highprecision imaging methods in routine practice.Objective: To determine topographic features of local complications of ...
Olga A. Tseneva, Elena V. Moiseenkova, Dmitriy A. Doroshenko, Sergei V. Mikhailusov, Viktor D. Anosov, Muhamed A. Hokonov, Vadim T. Koroshvili   +6 more
doaj   +1 more source

Trans fatty acids increase nitric oxide levels and pancreatic beta-cell necrosis in rats [PDF]

Universa Medicina, 2013
Background The prevalence of diabetes in Indonesia is increasing due to various factors, including life style changes such as trans fatty acid (TFA) intake.
Kusmiyati Tjahjono DK, Santoso, Dwi Ngestiningsih   +2 more
doaj  

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Treatment of acute complicated pancreatic pseudocysts

Journal of Education, Health and Sport, 2017
The results of surgery in 70 patients with acute complicated pancreatic pseudocysts in age from 21 to 79 years were analyzed. For patients using an individualized medical – diagnostic campaign, which primarily was aimed at the elimination of ...
I. A. Kryvoruchko, N. M. Goncharova, V. F. Gontar   +2 more
doaj  

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Inguinoscrotal region as an unusual site of extra-pancreatic collections in infected pancreatic necrosis [PDF]

, 2015
Saurabh Kalia, Rahul Gupta, Sunil D. Shenvi, Hemanth Kumar, Rajesh Gupta, Mandeep Kang, Surinder Singh Rana, Deepak K. Bhasin, Rajinder Singh   +8 more
openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source