Results 161 to 170 of about 1,102,866 (400)

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Novel classification system for walled-off pancreatic necrosis: a step in the right direction [PDF]

, 2023
Harshavardhan Telaprolu, Deshidi Srinu, Uday Kiran Mangipudi, Abhishek Yadav, Vaneet Jearth, Jimil Shah, Surinder Singh Rana   +6 more
openalex   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

An exacerbation of hemorrhagic vasculitis with the development of hemorrhagic necrotizing pancreatitis in a patient at an early stage after kidney retransplantation (case report)

Трансплантология (Москва), 2016
The clinical case report covers rare complications of hemorrhagic vasculitis manifested in the form of macrofocal hemorrhagic pancreatic necrosis that occurred in a patient at an early stage after kidney retransplantation.
O. N. Rzhevskaya, A. V. Pinchuk, A. G. Balkarov, A. S. Kondrashkin, I. V. Khodilina, S. V. Shvarts   +5 more
doaj  

Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines [PDF]

Thalidomide is an immunomodulatory and anti-inflammatory agent and is used in autoimmune disorders. It has been shown that thalidomide inhibits proinflammatory cytokines production.
امیرشاهرخی, کیوان, قاضی خوانساری, محمود   +1 more
core   +1 more source

Use of monoclonal antibodies for detection of infectious pancreatic necrosis virus by the enzyme-linked immunosorbent assay (ELISA)

, 1990
Javier Domı́nguez, RP Hedrick, José Manuel Sánchez‐Vizcaíno   +2 more
openalex   +1 more source

Primary squamous cell carcinoma of pancreas mimicking walled-off pancreatic necrosis [PDF]

, 2016
Deepak Gunjan, Surinder Singh Rana, Puneet Chhabra, Rahul V. Parghane, Rajesh Kumar, Lovneet Dhalaria, Bhawant R. Mittal, Deepak K. Bhasin   +7 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source