Results 31 to 40 of about 1,632 (216)

Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition

open access: yesMediators of Inflammation, 2020
Aplysin is a brominated sesquiterpene with an isoprene skeleton and has biological activities. The purpose of this study is to investigate the inhibitory effect of aplysin on spontaneous pancreatic necrosis in nonobese diabetic (NOD) mice and its ...
Ying Liu   +7 more
doaj   +1 more source

Complex Application of Minimally Invasive Methods for the Treatment of Complicated Acute Severe Pancreatitis

open access: yesНеотложная медицинская помощь, 2022
Percutaneous interventions for the purpose of sanation of cavities of pancreatogenic destruction can be one of the ways to treat pancreatic necrosis. This leads to a rapid cleansing of the cavities and is an objective method of monitoring the stages of ...
M. L. Rogal   +7 more
doaj   +1 more source

The role of endogenous insulin in patients with acute pancreatitis

open access: yesMìžnarodnij Endokrinologìčnij Žurnal
Background. Acute pancreatitis is an inflammatory disease of the exocrine part of the pancreas, accompanied by various complications and further development of necrosis of the gland and parapancreatic tissue with possible secondary infection.
O.I. Dronov   +5 more
doaj   +1 more source

Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis

open access: yesBMC Gastroenterology, 2012
Background The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with ...
Jürgensen Christian   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Open necrosectomy in acute pancreatitis–obsolete or still useful?

open access: yesWorld Journal of Emergency Surgery, 2020
Background Multiple organ failure and early surgery are associated with high morbimortality after open necrosectomy. Data are mostly derived from historical cohorts with early necrosectomy bereft of step-up treatment algorithm implementation.
Henrik Leonard Husu   +3 more
doaj   +1 more source

Systematic Review with Trial Sequential Analysis of Prophylactic Antibiotics for Acute Pancreatitis

open access: yesAntibiotics, 2022
Background/Objectives: Prophylactic antibiotics (PAB) are being still widely used for treatment of acute pancreatitis (AP) despite trials showing no firm evidence of efficacy. We aimed to evaluate effects of PAB for AP in a meta-analysis and the need for
Goran Poropat   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

LOCAL ANTIBACTERIAL TREATMENT IN PATIENTS WITH INFECTED PANCREATIC WALLED-OFF NECROSIS: A SYSTEMATIC REVIEW

open access: yesКлінічна та профілактична медицина
Introduction. Systemic antibacterial treatment in patients with infected pancreatic necrosis often fails to resolve the infection due to impaired penetration in necrotic areas.
Nizar R. Kerbazh   +5 more
doaj   +1 more source

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