Results 31 to 40 of about 91,441 (311)

Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. [PDF]

, 2016
Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a BRAF-V600E mutation to determine the efficacy of temozolomide (TEM ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Singh, Arun, Unno, Michiaki, Zhang, Yong, Zhao, Ming   +14 more
core   +2 more sources

Occurrence of acute oesophageal necrosis (black oesophagus) in a single tertiary centre [PDF]

, 2019
Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction.
Annibale, Bruno, Carabotti, Marilia, Corleto, Vito Domenico, DI GIULIO, Emilio, Esposito, Gianluca, Orlando, Davide, Ruggeri, Maurizio   +6 more
core   +1 more source

Managing Infected Pancreatic Necrosis

Chirurgia, 2018
The management of infected pancreatic necrosis has historically been based on early, open necrosectomy, associated with significant mortality. In recent years, an evidence based transformation has occurred towards the step-up approach consisting of percutaneous catheter drainage, if necessary, followed by minimally invasive necrosectomy.
John-Edwin, Thomson, Sven M, Van Dijk, Martin, Brand, Hjalmar C, Van Santvoort, Marc G, Besselink   +4 more
openaire   +2 more sources

EUS-Guided Multitransgastric Endoscopic Necrosectomy for Infected Pancreatic Necrosis with Noncontagious Retroperitoneal and Peritoneal Extension

Gut and Liver, 2010
Endoscopic necrosectomy was introduced as a safe and effective treatment modality for infected pancreatic necrosis. Although there have been many reports of endoscopic drainage of retroperitoneal pancreatic necrosis, the optimal endoscopic management of ...
doaj   +1 more source

Necrotizing colitis complicating necrotized pancreatitis: look out for intestinal pneumatosis

Journal of the Belgian Society of Radiology, 2013
Acute pancreatitis is a common cause of acute abdominal pain and is associated with a wide variety of complications. Pancreatic necrosis is one of the most important complications and is considered to be the most important indicator of disease severity ...
MA Siddiqui, A Jain, SAA Rizvi, K Ahmad, E Ullah, I Ahmad   +5 more
doaj   +1 more source

Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition

Mediators of Inflammation, 2020
Aplysin is a brominated sesquiterpene with an isoprene skeleton and has biological activities. The purpose of this study is to investigate the inhibitory effect of aplysin on spontaneous pancreatic necrosis in nonobese diabetic (NOD) mice and its ...
Ying Liu, Xinyue Cui, Ming-Qing Gao, Meilan Xue, Hongwei Xu, Zhishang Chang, Yushan Jiang, Hui Liang   +7 more
doaj   +1 more source

Local cryotherapy on the pancreas with pancreatic necrosis: Results of the experimental study

Acta Biomedica Scientifica, 2022
Background. Acute pancreatitis retains its leading position in the structure of urgent abdominal pathology, maintaining a high postoperative mortality, despite the emergence of new methods of surgical treatment.The aim of the study: to evaluate ...
S. S. Maskin, V. V. Aleksandrov, S. A. Petrenko, L. A. Igolkina   +3 more
doaj   +1 more source

The role of endogenous insulin in patients with acute pancreatitis

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Acute pancreatitis is an inflammatory disease of the exocrine part of the pancreas, accompanied by various complications and further development of necrosis of the gland and parapancreatic tissue with possible secondary infection.
O.I. Dronov, I.O. Kovalska, T.Yu. Ivanets, Ye.S. Kozachuk, L.V. Levchenko, U.V. Stasiuk   +5 more
doaj   +1 more source

Walled-off pancreatic necrosis

World Journal of Gastroenterology, 2010
Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the continually expanding knowledge about WOPN, by review of current data from references identified in Medline and PubMed, to September 2009 ...
Stamatakos, M., Stefanaki, C., Kontzoglou, K., Stergiopoulos, S., Giannopoulos, G., Safioleas, M.   +5 more
openaire   +3 more sources

Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis

BMC Gastroenterology, 2012
Background The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with ...
Jürgensen Christian, Arlt Alexander, Neser Frank, Fritscher-Ravens Annette, Stölzel Ulrich, Hampe Jochen   +5 more
doaj   +1 more source