Results 41 to 50 of about 91,441 (311)

Open necrosectomy in acute pancreatitis–obsolete or still useful?

World Journal of Emergency Surgery, 2020
Background Multiple organ failure and early surgery are associated with high morbimortality after open necrosectomy. Data are mostly derived from historical cohorts with early necrosectomy bereft of step-up treatment algorithm implementation.
Henrik Leonard Husu, Jouni Antero Kuronen, Ari Kalevi Leppäniemi, Panu Juhani Mentula   +3 more
doaj   +1 more source

Correlative factor of death in patients with infected pancreatic necrosis after surgical intervention

Journal of Pancreatology, 2022
Background:. Acute pancreatitis (AP) was a potentially fatal disease with a variation in severity. Infected pancreatic necrosis was a common complication in AP which needed surgical intervention.
Yuhui Chen, Zhiwei Liu, Shouwang Cai
doaj   +1 more source

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. [PDF]

, 2016
A patient with high grade undifferentiated pleomorphic soft-tissue sarcoma from a striated muscle was grown orthotopically in the right biceps femoris muscle of mice to establish a patient-derived orthotopic xenograft (PDOX) model.
Bouvet, Michael, Chawla, Sant, Chishima, Takashi, DeLong, Jonathan, Deng, Samantha, Eilber, Fritz C, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Matsuyama, Ryusei, Murakami, Takashi, Quan, Cuong, Reynoso, Jose, Russell, Tara, Singh, Arun, Tanaka, Kuniya, Zhang, Nan, Zhang, Yong, Zhao, Ming   +18 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Personalized prediction of acute kidney injury in patients with pancreatic necrosis

Вестник анестезиологии и реаниматологии, 2023
Relevance. The incidence of acute pancreatitis is growing worldwide, being one of the leading causes of hospitalization in urgent surgery. The most common complication of pancreatic necrosis (PN) in the aseptic phase is acute kidney injury (AKI), which ...
A. V. Lopushkov, M. I. Turovets, N. Sh. Burchuladze, A. S. Popov, E. N. Zyubina, E. G. Spiridonov, I. G. Kandybina, A. A. Vorobyova, I. V. Mikhin   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

LOCAL ANTIBACTERIAL TREATMENT IN PATIENTS WITH INFECTED PANCREATIC WALLED-OFF NECROSIS: A SYSTEMATIC REVIEW

Клінічна та профілактична медицина
Introduction. Systemic antibacterial treatment in patients with infected pancreatic necrosis often fails to resolve the infection due to impaired penetration in necrotic areas.
Nizar R. Kerbazh, Daniel de la Iglesia, Jose Larino-Noia, Julio Iglesias-Garcia, Serhii I. Panasenko, Juan E. Dominguez-Munoz   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Acute Pancreatitis (A Clinical Case)

Креативная хирургия и онкология
ntroduction. The diagnosis of acute pancreatitis poses no significant difficulties. Nonetheless, accurately predicting the potential severity of the disease during its early stages remains a challenge with existing diagnostic methods.
A. I. Khripun, A. N. Alimov, S. Yu. Orlov, T. P. Chelyapina   +3 more
doaj   +1 more source