Results 81 to 90 of about 1,632 (216)
Advanced Science, EarlyView.Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.The strategy of engineering nanogel network topology is developed to achieve iterative activation of mechanophores upon high‐frequency and low‐intensity ultrasound. This places the nanogel system among the systems that can respond to the ultrasound with the highest frequency and lowest intensity as well as have the fastest activation rate so far.
Helin Li +7 more
wiley +2 more sources
Advanced Science, EarlyView.Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Here, we enhance the electrochemiluminescence imaging of cellular spheroids using [Ru(bpy)3]2+/TPrA chemistry. Our strategy, which involves pre‐incubation with TPrA, enables high‐resolution, long‐term visualization of cellular spheroids without phototoxicity.
Vanshika Gupta +5 more
wiley +2 more sources
Protein kinase D regulates cell death pathways in experimental pancreatitis
Frontiers in Physiology, 2012 Inflammation and acinar cell necrosis are two major pathological responses of acute pancreatitis, a serious disorder with no current therapies directed to its molecular pathogenesis. Serine/threonine protein kinase D family, which includes PKD/PKD1, PKD2,
Jingzhen eYuan +12 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Aim The National Clinical Database (NCD) of Japan is the largest nationwide registry, covering over 95% of surgeries in the country. This 2022 annual report summarizes the short‐term outcomes of gastroenterological surgeries and discusses trends and insights over the past decade.
Koshi Kumagai +19 more
wiley +1 more source
Вестник хирургии имени И.И. Грекова, 2018 OBJECIVE. The evaluation of predictive significance of DNA damage of mononuclear blood cells in patients with pancreatic necrosis. MATERIAL AND METHODS.
V. V. Saveliev +2 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.Emergency cholecystectomy was evaluated in patients with acute cholecystitis classified as non‐recommended for surgery by the Tokyo Guidelines 2018. Major postoperative complications, rather than mortality, better reflected operative risk. Physiological instability, particularly ASA‐PS ≥ 3 and shock status, identified high‐risk patients, suggesting ...
Satoshi Mii +9 more
wiley +1 more source
The Pathogenesis of Acute Pancreatic Hemorrhage and Pancreatic Necrosis [PDF]
The American Journal of the Medical Sciences, 1907 n ...
openaire +1 more source
Annals of Gastroenterological Surgery, EarlyView.Feeding enterostomy during MIE was evaluated in 19 054 patients from the Japanese NCD using propensity weighting. Enterostomy was associated with higher reoperation and respiratory complications, but lower delayed gastric emptying and deep vein thrombosis, with no significant difference in overall bowel obstruction.
Eisuke Booka +7 more
wiley +1 more source