Results 231 to 240 of about 297,195 (347)

Pancreatic Cystic Neoplasms: The Challenges in Diagnosis and Review of Treatment

, 2020
Ma RT, Yongfei Guo, Jiang Xie, Huang Ly
openalex   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Cell-Free Tumor DNA Detection-Based Liquid Biopsy of Plasma and Bile in Patients with Various Pancreatic Neoplasms. [PDF]

Biomedicines
Jain M, Atayan D, Rakhmatullin T, Dakhtler T, Popov P, Kim P, Viborniy M, Gontareva I, Samokhodskaya L, Egorov V.   +9 more
europepmc   +1 more source

ABO Blood Group and the Risk of Pancreatic Neoplasms in Chinese Han Population: A Study at Shanghai Pancreatic Cancer Institute. [PDF]

Pancreas, 2019
Liu M, Ji S, Xu W, Liu W, Qin Y, Xiang J, Hu Q, Sun Q, Zhang Z, Xu X, Yu X.   +10 more
europepmc   +1 more source

Follow-Up Report of a Case of Solid-Pseudopapillary Pancreatic Neoplasm with Four Resections in 30 Years

Daiki Horiba, Hiroyuki Sugimoto, Naoki Mashita, Masayuki Tsutsuyama, Daisuke Kobayashi, Yoshinari Mochizuki, Kenji Taniguchi   +6 more
openalex   +2 more sources

Ultrasonographic diagnosis for pancreatic neoplasms

, 2010
Hiroyuki Maguchi, Manabu Osanai, Akio Katanuma, Kuniyuki Takahashi   +3 more
openalex   +2 more sources

Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms [PDF]

, 2014
Elisabetta Buscarini, Raffaele Pezzilli, Renato Cannizzaro, Claudio De Angelis, Massimo Gion, Giovanni Morana, Giuseppe Zamboni, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Luca Barresi, Daniela Basso, Paolo Bocus, Lucia Calculli, Gabriele Capurso, Vincenzo Canzonieri, Riccardo Casadei, Stefano Crippa, Mirko D’Onofrio, Luca Frulloni, Pietro Fusaroli, Guido Manfredi, Donatella Pacchioni, Claudio Pasquali, Rodolfo Rocca, M. Ventrucci, Silvia Venturini, Vincenzo Villanacci, Alessandro Zerbi, Massimo Falconi, Luca Albarello, Lorenzo Camellini, P. Cantù, Rita Conigliaro, Guido Costamagna, G. Del Favero, G. Del Vecchio Blanco, Pierluigi Di Sebastiano, Carlo Fabbri, Pier Venanzio Federici, Niccola Funel, Andrea Galli, Armando Gabbrielli, Rossella Graziani, Tiziana Guadagnini, Andrea Laghi, Giampiero Macarri, Fabrizio Magnolfi, Marco Marzioni, Fabio Monica, Nicola Muscatiello, Massimiliano Mutignani, A Pisani, Enrico Scarano, Carla Serra, Marco Spada, M. Visconti, Alessandro Zambelli   +56 more
openalex   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source