Results 231 to 240 of about 977,911 (341)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Low interobserver agreement in cytology grading of mucinous pancreatic neoplasms

Cancer Cytopathology, 2015
C. Sigel, M. Edelweiss, L. C. Tong, J. Magda, H. Oen, K. Sigel, M. Zakowski   +6 more
semanticscholar   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Endoscopic Ultrasound Imaging for Differential Diagnosis of Pancreatic Neoplasms: A 7-Year Study in a Chinese Population. [PDF]

Med Sci Monit, 2018
Cui B, Fang W, Khan S, Li S, Chang Y, Wang B, Liu W.   +6 more
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20%

Modern Pathology, 2017
B. Konukiewitz, A. Schlitter, M. Jesinghaus, D. Pfister, K. Steiger, A. Segler, A. Agaimy, B. Sipos, G. Zamboni, W. Weichert, I. Esposito, N. Pfarr, G. Klöppel   +12 more
semanticscholar   +1 more source

Endoscopic ultrasound-guided therapies in pancreatic neoplasms. [PDF]

Biomed Res Int, 2015
Yang D, DiMaio CJ.
europepmc   +1 more source

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

Radiology of pancreatic neoplasms: An update. [PDF]

World J Gastrointest Oncol, 2014
de la Santa LG, Retortillo JA, Miguel AC, Klein LM.   +3 more
europepmc   +1 more source

Contribution of organ transplantation to the biology of cancer [PDF]

, 1990
Starzl, TE
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