Results 291 to 300 of about 176,259 (332)

Unraveling the Microenvironment and the Pathogenic Axis of HIF‐1α–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single‐Cell Atlas

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Single‐cell RNA sequencing reveals that type 1 AIP exhibits increased amount and subtypes of B and plasma cells, particularly IgG4+ plasma cells, along with an expansion of Tfh and T helper CD4+ cells. Both AIP types share upregulation of HIF1A+ classical monocytes, which promote pancreatic fibrosis through increased visfatin production.
Deyu Zhang, Congjia Ma, Zhen Wang, Yanfang Liu, Zaoqu Liu, Wanshun Li, Yue Liu, Chang Wu, Liqi Sun, Fei Jiang, Hui Jiang, Xiaoju Su, Lisi Peng, Jiayu Li, Xinyue Wang, Hua Yin, Dongling Wan, Yuyan Zhou, Xiaorong Tian, Shiyu Li, Zhendong Jin, Baoan Ji, Zhaoshen Li, Haojie Huang   +23 more
wiley   +1 more source

Laparoscopic spleen-preserving distal pancreatectomy for pancreatic neoplasms: a retrospective study. [PDF]

World J Gastroenterol, 2014
Yan JF, Xu XW, Jin WW, Huang CJ, Chen K, Zhang RC, Harsha A, Mou YP.   +7 more
europepmc   +1 more source

Pancreatic cystic neoplasms: Predictors of malignant behavior and management

, 2013
Ayman El Nakeeb, Ehab Atef, Ehab El Hanafy, Mohamed El-Hemaly, Emad Hamdy, Ahmed Elgeidie   +5 more
openalex   +1 more source

Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Necroptosis, a key driver of disease progression, holds promise for activating antitumor immunity. The optogenetically controlled necroptosis system, optoMLKL, bypasses upstream signaling, forming functional hotspots in membranes without RIPK3 phosphorylation.
Da‐Hye Jeong, Seokhwi Kim, Han‐Hee Park, Kyoung‐Jin Woo, Jae‐Il Choi, Minji Choi, Jisoo Shin, So Hyun Park, Myung‐Wook Seon, Dakeun Lee, Jong‐Ho Cha, You‐Sun Kim   +11 more
wiley   +1 more source

Castleman’s Disease Presenting as Peri - Pancreatic Neoplasm

, 2014
Preethi S. Shetty, Shraddha Patkar, Tanuja Shet, Mahesh Goel, Shailesh V. Shrikhande   +4 more
openalex   +2 more sources

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The study identifies MSN as a key regulator of proneural‐to‐mesenchymal transition (PMT) in GSCs, driving resistance to radiotherapy (RT) and temozolomide (TMZ) in glioblastoma (GBM). However, GNE‐317 specifically inhibits MSN, reverses PMT, resensitizes cells to therapy, and shows promise as a targeted strategy to overcome chemoradiotherapy resistance
Yong‐Chang Yang, Xing‐Yu Jin, Ling‐Ling Yang, Xing Xu, Yang Xie, Yi‐Ding Ai, Xin‐Chao Li, Ye‐Cheng Ma, Cheng‐Long Xu, Qi Li, Xiang‐Lian Ge, Tai‐Long Yi, Tao Jiang, Xiao‐Guang Wang, Ying‐Zhe Piao, Xun Jin   +15 more
wiley   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source