Results 311 to 320 of about 861,721 (390)

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Diagnosis of and Therapy for Pancreatic Neoplasms

Nihon Naika Gakkai Zasshi, 2007
openaire   +3 more sources

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

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Deep Learning-based Detection of Solid and Cystic Pancreatic Neoplasms at Contrast-enhanced CT.

Radiology, 2022
Background Deep learning (DL) may facilitate the diagnosis of various pancreatic lesions at imaging. Purpose To develop and validate a DL-based approach for automatic identification of patients with various solid and cystic pancreatic neoplasms at ...
H. Park, Keewon Shin, Myung-Won You, Sunggu Kyung, So Yeon Kim, Seong Ho Park, J. Byun, Nam-Don Kim, Hyoung-Jung Kim   +8 more
semanticscholar   +1 more source

Endoscopic ablation therapy for the pancreatic neoplasms

Digestive Endoscopy, 2022
Recently, endoscopic ultrasound (EUS)‐guided ablation therapy has been reported as a less invasive therapy for patients with pancreatic neoplasms.
Kazuyuki Matsumoto, Hironari Kato
semanticscholar   +1 more source

Pancreatic Neoplasms

Gastrointestinal Endoscopy Clinics of North America, 2005
Abstract Almost uniformly, cancer of the pancreas is fatal and is increasingly a health problem. In the United States, the calculated incidence of pancreatic cancer in 2008 was 37,700, with 34,300 deaths due to the disease. The overall survival rate for persons with pancreatic cancer is less than 5%, the lowest 5-year survival rate of ...
Michael J, Levy, Maurits J, Wiersema
openaire   +3 more sources

Pancreatic Cystic Neoplasms

Surgical Clinics of North America, 2010
Cystic neoplasms of the pancreas have been recognized for almost 2 centuries, but the principles of management continue to evolve. Clinicians have a better understanding now of the diverse pathologies and behaviors of cystic neoplasms, and can characterize them more precisely into benign, malignant, and of uncertain potential in their manifestations ...
J. Lawrence Munson, Jennifer Verbesey
openaire   +6 more sources