Results 41 to 50 of about 34,133 (252)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Clinical characteristics and long-term outcomes following pancreatic injury – An international multicenter cohort study

Heliyon, 2023
Background: Trauma to the pancreas is rare but associated with significant morbidity. Currently available management guidelines are based on low-quality evidence and data on long-term outcomes is lacking.
Laura L. Meijer, Yrjö Vaalavuo, Sara Regnér, Ville Sallinen, Aurora Lemma, Urban Arnelo, Roberto Valente, Sofia Westermark, David An, John A.G. Moir, Ellen A. Irwin, Esther A. Biesel, Ulrich T. Hopt, Stefan Fichtner-Feigl, Uwe A. Wittel, Maximilian Weniger, Henning Karle, Frank W. Bloemers, Robert Sutton, Richard M. Charnley, Dietrich A. Ruess, Peter Szatmary   +21 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

FEATURES OF DIAGNOSTIC AND THERAPEUTIC TACTICS FOR BLUNT ABDOMINAL TRAUMA WITH DAMAGE TO THE PANCREAS

Неотложная медицинская помощь, 2017
. Injuries of pancreas in the closed abdominal trauma remain the one of most challenging issues in diagnosis and choice of optimal therapy.Objectives.
A. B. Singayevsky, S. G. Scherbak, B. V. Sigua, N. M. Vrublevsky, A. V. Nikiforenko, A. A. Kurkov, A. K. Dyukov   +6 more
doaj   +1 more source

Pancreatic Injury Involving Bicycle Handlebar in a Pediatric Patient [PDF]

Pediatric Emergency Medicine Journal, 2014
Significant pancreatic injuries can occur with minor handlebar trauma. Timely diagnosis of pancreatic injuries is critically important, since delayed diagnosis is the greatest determinant of morbidity.
Jea Yeon Choi, Young Ho Kwak, Do Kyun Kim, Jae Yun Jung, Dongbum Suh, Ikwan Chang   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Experience of surgical treatment of combat pancreatic trauma

Медицина неотложных состояний
Background. Pancreatic injuries is a complex challenge for trauma surgeons, especially if combat, due to the presence of combined injuries and complications.
Е.М. Хорошун, І.П. Хоменко, С.А. Шипілов, В.В. Макаров, В.В. Негодуйко, О.Г. Петюнін   +5 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

A non-operative strategy for grade IV blunt pancreatic trauma

Journal of Pediatric Surgery Case Reports, 2019
Pancreatic injuries are relatively uncommon in the pediatric population but when present, they can be a challenge to the surgeon in terms of diagnosis and management. When the injury involves the pancreatic duct it has a major impact on patient's outcome
Téa Sue, Melania Matcovici, Sri Paran
doaj   +1 more source