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Reactome - a knowledgebase of human biological pathways [PDF]

open access: yes, 2007
Pathway curation is a powerful tool for systematically associating gene products with functions. Reactome (www.reactome.org) is a manually curated human pathway knowledgebase describing a wide range of biological processes in a computationally accessible
Bernard de Bono   +12 more
core   +2 more sources

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou   +6 more
wiley   +1 more source

Integrated Transcriptomic, Proteomic, and Network Pharmacology Analyses Unravel Key Therapeutic Mechanisms of Xuebijing Injection for Severe Acute Pancreatitis

open access: yesPharmaceuticals
Background: Xuebijing Injection (XBJ), a plant-derived traditional Chinese medicine administered as an injection, is widely used in clinical practice to treat various acute critical illnesses including severe acute pancreatitis (SAP).
Linbo Yao   +17 more
doaj   +1 more source

AKI Associated with Acute Pancreatitis.

open access: yesAmerican Society of Nephrology. Clinical Journal, 2019
Acute pancreatitis is a common disorder of the pancreas. It is the most frequent gastrointestinal cause for hospitalization and one of the leading causes of in-hospital deaths.
T. Nassar, W. Qunibi
semanticscholar   +1 more source

Multicenter Validation Study of the Clinical Diagnostic Criteria for IgG4‐Related Sclerosing Cholangitis 2020 in Japan

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background The diagnostic performance of clinical diagnostic criteria for IgG4‐related sclerosing cholangitis 2020 (IgG4‐SC2020) has not been fully validated since its proposal as a revision of the 2012 criteria (IgG4‐SC2012). Methods We conducted a multicenter validation study to evaluate the diagnostic performance of IgG4‐SC2020 using ...
Itaru Naitoh   +60 more
wiley   +1 more source

Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms

open access: yesEcotoxicology and Environmental Safety
Dichlorvos (DDVP) is an organophosphorus pesticide commonly utilized in agricultural production. Recent epidemiological studies suggest that exposure to DDVP correlates with an increased incidence of liver disease.
Pengcheng Zhang   +11 more
doaj   +1 more source

The use of complementary and alternative medicine is frequent in patients with pancreatic disorder [PDF]

open access: yes, 2016
BACKGROUND: Herbal remedies and other complementary and alternative medicine (CAM) are used by 30% of the patients with liver and inflammatory bowel diseases.
Archibugi, L   +4 more
core   +1 more source

Evaluation and management of acute pancreatitis

open access: yesWorld Journal of Clinical Cases, 2019
Acute pancreatitis (AP) is one of the most common gastrointestinal causes for hospi-talization in the United States. In 2015, AP accounted for approximately 390000 hospitalizations. The burden of AP is only expected to increase over time.
A. Chatila, M. Bilal, Praveen Guturu
semanticscholar   +1 more source

Comparative Outcomes of Endoscopic Treatment for Symptomatic and Asymptomatic Common Bile Duct Stones in the Elderly: A Propensity Score‐Based Cohort Analysis

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Various guidelines recommend endoscopic stone removal for asymptomatic common bile duct stones (CBDS); however, previous studies have indicated that asymptomatic CBDS is associated with a higher incidence of post‐ERCP pancreatitis (PEP).
Kota Shimojo   +9 more
wiley   +1 more source

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