Results 121 to 130 of about 198,132 (219)

Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction

Nature Communications
Nutrient-sensing pathways undergo deregulation in aged animals, exerting a pivotal role in regulating the cell cycle and subsequent stem cell division.
Zihua Yu, Yuedan Zhu, Yi Chen, Chenxi Feng, Zehong Zhang, Xiaoxin Guo, Haiou Chen, Xingzhu Liu, Yu Yuan, Haiyang Chen   +9 more
doaj   +1 more source

Current Endoscopic and Surgical Management of Pancreatic Cystic Lesions: A Comprehensive Review

The Turkish Journal of Gastroenterology
Pancreatic cystic lesions (PCLs) are frequent incidental findings with an increasing prevalence with age. For these significant lesions, accurate characterization of cyst type and prediction of the risk of malignant progression are crucial for specific ...
Kunzah A. Syed , Elham Afghani, Kelly J. Lafaro   +2 more
doaj   +1 more source

Vitamin B12 protects necrosis of acinar cells in pancreatic tissues with acute pancreatitis

MedComm
Pharmacological agents regarding the most optimal treatments of acute pancreatitis remain. One‐carbon metabolism nutrients as therapeutic agents in many diseases might be involved in acute pancreatitis.
Yulin Chen, Xue Li, Ran Lu, Yinchun Lv, Yongzi Wu, Junman Ye, Jin Zhao, Li Li, Qiaorong Huang, Wentong Meng, Feiwu Long, Wei Huang, Qing Xia, Jianbo Yu, Chuanwen Fan, Xianming Mo   +15 more
doaj   +1 more source

Pancreatic Tumor Segmentation as Anomaly Detection in CT Images Using Denoising Diffusion Models [PDF]

arXiv
Despite the advances in medicine, cancer has remained a formidable challenge. Particularly in the case of pancreatic tumors, characterized by their diversity and late diagnosis, early detection poses a significant challenge crucial for effective treatment.
arxiv  

Cross-Organ Domain Adaptive Neural Network for Pancreatic Endoscopic Ultrasound Image Segmentation [PDF]

arXiv
Accurate segmentation of lesions in pancreatic endoscopic ultrasound (EUS) images is crucial for effective diagnosis and treatment. However, the collection of enough crisp EUS images for effective diagnosis is arduous. Recently, domain adaptation (DA) has been employed to address these challenges by leveraging related knowledge from other domains. Most
arxiv  

The Batten disease gene Cln3 is required for the activation of intestinal stem cell during regeneration via JAK/STAT signaling in Drosophila

Frontiers in Cell and Developmental Biology
CLN3 mutation causes Juvenile neuronal ceroid lipofuscinosis (JNCL, also known as Batten disease), an early onset neurodegenerative disorder. Patients who suffer from Batten disease often die at an early age.
Zihua Yu, Zihua Yu, Jinhua Yan, Zhiming Liu, Haiyan Wang, Guanzheng Luo, Haiyang Chen   +6 more
doaj   +1 more source

In Silico Pharmacokinetic and Molecular Docking Studies of Natural Plants against Essential Protein KRAS for Treatment of Pancreatic Cancer [PDF]

arXiv
A kind of pancreatic cancer called Pancreatic Ductal Adenocarcinoma (PDAC) is anticipated to be one of the main causes of mortality during past years. Evidence from several researches supported the concept that the oncogenic KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene) mutation is the major cause of pancreatic cancer. KRAS acts as an on-off switch
arxiv  

Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages

Frontiers in Pharmacology
BackgroundIsatidis Folium, a botanical drug widely used in traditional medicine, is known for its anti-inflammatory properties, including heat-clearing, detoxifying, and blood-cooling effects. Although its potential in sepsis treatment has been suggested,
Yancen Li, Chengyu Wan, Fan Li, Guang Xin, Tao Wang, Qilong Zhou, Tingyu Wen, Shiyi Li, Xiaoting Chen, Wen Huang   +9 more
doaj   +1 more source

Genetic insights into across pancreatitis types: the causal influence of immunoglobulin G N-glycosylation variants on disease risk

Frontiers in Immunology
BackgroundWhile a few case-control studies indicated a possible correlation of IgG N-glycosylation patterns with pancreatitis, their restricted sample sizes and methodologies prevented conclusive insights into causality or distinguishing traits across ...
Yulin Chen, Xue Li, Ran Lu, Ran Lu, Ran Lu, Yinchun Lv, Junman Ye, Qiaorong Huang, Wentong Meng, Feiwu Long, Jonas Burman, Xianming Mo, Chuanwen Fan, Chuanwen Fan   +13 more
doaj   +1 more source

Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overview

Biomedical Papers
This is an overview of relation between acute and chronic pancreatitis and between acute pancreatitis and pancreatic cancer. Acute pancreatitis and recurrent acute pancreatitis are an etiological factor of chronic pancreatitis.
David Solil, Petr Dite, Michal Senkyrik, Martina Bojkova, Bohuslav Kianicka   +4 more
doaj   +1 more source