Results 101 to 110 of about 183,025 (305)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Case Report: A rare case of concurrent diabetic ketoacidosis and severe acute pancreatitis, followed by Guillain-Barré syndrome and Wernicke’s encephalopathy

Frontiers in Endocrinology
The coexistence of diabetic ketoacidosis (DKA) and severe acute pancreatitis (SAP) is a life-threatening metabolic emergency complicated by multiple organ dysfunction syndrome.
Chanjuan Chen, Youjin Zhao, Xiyu Lin, Xiaoxin Zhang, Jia Guo, Ziqi Lin   +5 more
doaj   +1 more source

Caracterización clínica de los pacientes con pancreatitis aguda atendidos en el servicio de gastroenterología del Hospital de Especialidades Eugenio Espejo desde enero del 2018 hasta diciembre de 2020 [PDF]

, 2022
Introducción: La pancreatitis aguda (PA) es una de las enfermedades gastrointestinales que comúnmente requiere hospitalización. Tiene una incidencia anual variable que va en aumento con el transcurso del tiempo. En Ecuador, según las cifras obtenidas del
Quingalombo Cargua, Gabriela Fernanda, Zambrano Flores, Estíbalys Nahomi   +1 more
core  

Unfractionated Heparin and Low‐Molecular‐Weight Heparin in Sepsis: Anti‐Inflammatory and Anticoagulant Effects Versus No Anticoagulation—A Propensity Score‐Matched Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
This propensity score‐matched study compared unfractionated heparin (UFH) and low‐molecular‐weight heparin (LMWH) in 1362 sepsis patients, finding that both significantly improved survival without increasing 90‐day bleeding risk. However, their therapeutic mechanisms differed: UFH demonstrated broader anti‐inflammatory effects by reducing IL‐6, IL‐8 ...
Peili Chen, Yi Yao, Bing Zhao, Yuan An, Jian Jiang, Li Ma, Enqiang Mao, Yihui Wang   +7 more
wiley   +1 more source

Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms

Ecotoxicology and Environmental Safety
Dichlorvos (DDVP) is an organophosphorus pesticide commonly utilized in agricultural production. Recent epidemiological studies suggest that exposure to DDVP correlates with an increased incidence of liver disease.
Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang   +11 more
doaj   +1 more source

Whole-Exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-Organ Failure in Acute Pancreatitis [PDF]

, 2022
OBJECTIVE: The aim of this study was to identify genetic variants associated with early multiple organ failure (MOF) in acute pancreatitis. SUMMARY BACKGROUND DATA: MOF is a life-threatening complication of acute pancreatitis, and risk factors are ...
Dutch Pancreatitis Study Group
core  

Clinical Evaluation of the Effectiveness of Digital Peroral Cholangioscopy‐Guided Lithotripsy for Difficult Bile Duct Stones

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Aims Peroral cholangioscopy‐guided lithotripsy (POCS‐L) has emerged as a treatment option for difficult bile duct stones (DBDSs), but detailed evidence remains limited. This study evaluated its effectiveness, safety, and risk factors for adverse events (AEs).
Hirohito Minami, Shuntaro Mukai, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kazumasa Nagai, Hiroyuki Kojima, Noriyuki Hirakawa, Kyoko Asano, Takao Itoi   +9 more
wiley   +1 more source

Akut pancreatitis konzervatív kezelésének ápolói nehézségei

, 2022
Szakdolgozatom témája az akut pancreatitis konzervatív kezelésének ápolói nehézségeiről szól,melyben az I.fázisban kutatást végeztem a munkahelyemen előforduló akut pancreatitisben szenvedő betegek ellátásáról.A betegség lefolyását elemeztem,statisztikát
Kocsárdi, Anikó
core  

Visceral Adipose Tissue as an Independent Predictor of Severe Post‐ERCP Pancreatitis: A Multicenter Retrospective Cohort Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), known as post‐ERCP pancreatitis (PEP), is a major adverse event. Although risk factors for PEP incidence have been widely studied, factors associated with severe PEP remain unclear.
Shinya Uemura, Takuji Iwashita, Takuya Koizumi, Yosuke Ohashi, Shota Iwata, Akinori Maruta, Keisuke Iwata, Masahito Shimizu   +7 more
wiley   +1 more source

Long‐Term Outcomes of Low‐Dose Steroid Induction for Autoimmune Pancreatitis: A Multicenter Retrospective Study Identifying Risk Factors for Relapse

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steroids are the first‐line treatment for autoimmune pancreatitis (AIP); however, the impact of lower initial doses on relapse remains unclear. Methods Ninety patients were divided into high‐dose (HD; > 0.4 mg/kg/day) and low‐dose (LD; ≤ 0.4 mg/kg/day) induction groups. The treatment response, relapse rate, and predictors of relapse
Yuhei Iwasa, Akinori Maruta, Keisuke Iwata, Hidetaka Kuroda, Shinya Uemura, Shota Iwata, Yosuke Ohashi, Naoki Mita, Hironao Ichikawa, Masahito Shimizu   +9 more
wiley   +1 more source