Results 81 to 90 of about 128,122 (265)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Changes of CEA Diagnostic Performance Under the New Reference Interval Stratified by Age and Sex

Journal of Clinical Laboratory Analysis, EarlyView.
Our study included patients with lung cancer, breast cancer, and colorectal cancer and apparently healthy individuals, conducted a large case–control study to assess the effects of age and sex on serum concentrations and positive rates of CEA, established age‐ and sex‐stratified reference intervals using indirect methods.
Ke Zhang, Xiarui Ye
wiley   +1 more source

Geniposide, a potential therapeutical candidate for acute pancreatitis, inhibited trypsinogen-activated CBS degradation and remodeled transsulfuration metabolic flux

Redox Biology
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options currently available. The premature activation of trypsinogen within acinar cells constitutes one of the pivotal early pathological events in AP, contributing to ...
Ji Gao, Yijing Long, Jiawang Li, Yiqin Wang, Rui Wang, Jinxi Yang, Jie Zhang, Chenxia Han, Qing Xia, Dan Du   +9 more
doaj   +1 more source

Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Graphical summary of the study design, intervention, and outcomes. ABSTRACT Background Patients with biliary tract cancer (BTC) often have actionable mutations, and comprehensive genomic profiling (CGP) plays an important role. However, the feasibility of CGP using transpapillary biopsy (TPB) samples remains unclear.
Kazuya Miyamoto, Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Hirohumi Inoue, Ryosuke Sato, Akihiro Matsumi, Yuki Fujii, Daisuke Uchida, Motoyuki Otsuka   +9 more
wiley   +1 more source

Clinical Evaluation of the Effectiveness of Digital Peroral Cholangioscopy‐Guided Lithotripsy for Difficult Bile Duct Stones

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Aims Peroral cholangioscopy‐guided lithotripsy (POCS‐L) has emerged as a treatment option for difficult bile duct stones (DBDSs), but detailed evidence remains limited. This study evaluated its effectiveness, safety, and risk factors for adverse events (AEs).
Hirohito Minami, Shuntaro Mukai, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kazumasa Nagai, Hiroyuki Kojima, Noriyuki Hirakawa, Kyoko Asano, Takao Itoi   +9 more
wiley   +1 more source

Visceral Adipose Tissue as an Independent Predictor of Severe Post‐ERCP Pancreatitis: A Multicenter Retrospective Cohort Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP), known as post‐ERCP pancreatitis (PEP), is a major adverse event. Although risk factors for PEP incidence have been widely studied, factors associated with severe PEP remain unclear.
Shinya Uemura, Takuji Iwashita, Takuya Koizumi, Yosuke Ohashi, Shota Iwata, Akinori Maruta, Keisuke Iwata, Masahito Shimizu   +7 more
wiley   +1 more source

Clinical progress note: Mumps

Journal of Hospital Medicine, EarlyView.
Abstract Mumps was a common childhood viral illness before the implementation of the measles, mumps, and rubella (MMR) vaccination in 1967. There was a significant decrease in mumps cases in the postvaccine era; however, there has been an increase in outbreaks in the United States over the past two decades.
Sarah Ludvigsen, Mati Segev
wiley   +1 more source

Autophagy and the pancreas: Healthy and disease states

Frontiers in Cell and Developmental Biology
Macroautophagy/autophagy is an intracellular degradation pathway that has an important effect on both healthy and diseased pancreases. It protects the structure and function of the pancreas by maintaining organelle homeostasis and removing damaged ...
Zixian Zhou, Pengcheng Zhang, Pengcheng Zhang, Juan Li, Jiaqi Yao, Yuhong Jiang, Meihua Wan, Wenfu Tang, Wenfu Tang, Ling Liu   +9 more
doaj   +1 more source

Outcomes of surgical versus conservative treatment in pediatric median arcuate ligament syndrome

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Median arcuate ligament syndrome (MALS) involves compression of the celiac artery and presents with gastrointestinal symptoms. We evaluated outcomes after surgical versus conservative management in pediatric MALS. Methods We reviewed charts of symptomatic patients aged 7–21 years diagnosed by ultrasound and/or computed tomography ...
Mohamad Abi Nassif, Juan Gurria, Danny Mallon, Rashmi Sahay, Lev Dorfman, Emily Vore, Jennifer Hardy, Kaitlin Whaley, Alex Nasr, Neha R. Santucci   +9 more
wiley   +1 more source

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source