Results 81 to 90 of about 166,885 (311)

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Frontiers in Physiology, 2020
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its ...
Xinmin Yang, Linbo Yao, Xianghui Fu, Rajarshi Mukherjee, Qing Xia, Monika A. Jakubowska, Pawel E. Ferdek, Wei Huang   +7 more
doaj   +1 more source

Whole-Exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-Organ Failure in Acute Pancreatitis [PDF]

, 2022
OBJECTIVE: The aim of this study was to identify genetic variants associated with early multiple organ failure (MOF) in acute pancreatitis. SUMMARY BACKGROUND DATA: MOF is a life-threatening complication of acute pancreatitis, and risk factors are ...
Dutch Pancreatitis Study Group
core  

Multidisciplinary Management of Acute and Chronic Pancreatitis

, 2023
Pancreatitis is a common disease of the digestive system with a high mortality and complication rate. The successful management of patients requires a multidisciplinary team of gastroenterologists, surgeons, interventional radiologists, and specialists ...

core   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Ketogenic diet therapy for children with super‐refractory status epilepticus in intensive care: International clinical practice recommendations

Epilepsia Open, EarlyView.
Abstract Objective We aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super‐refractory status epilepticus in intensive care settings. Methods A literature review was conducted to extract published data on patient selection, diet prescription, diet initiation, monitoring, fine‐
Robyn Blackford, Victoria J. Whiteley, Isobel Hardy, Marisa Armeno, Tessa Bollard, J. Helen Cross, Christin Eltze, Susan George, Charlotte Howard, A. Laura Nijstad, Erin Talzzia, Chris Paget, Samiran Ray, Zoe Simpson, Elizabeth Song‐Pozderac, Agnieszka Szmurlo, Charlene Tan‐Smith, Lisa Vanatta, Elles van der Louw, Natasha E. Schoeler, on behalf of the Ketogenic Dietitians Research Network   +20 more
wiley   +1 more source

Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study

Frontiers in Pharmacology
BackgroundAcute pancreatitis (AP) is a common digestive disorder, with necrotizing pancreatitis (NP) occurring in 20% of cases. Long-term complications can include pancreatic exocrine and endocrine insufficiency, with gut microbiota (GM) playing a ...
Jiongdi Lu, Jiongdi Lu, Zhe Wang, Zhe Wang, Feng Cao, Feng Cao, Jia Li, Guofeng Ji, Guofeng Ji, Fei Li, Fei Li   +10 more
doaj   +1 more source

Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study protocol for a multicentre cluster randomised controlled trial [PDF]

, 2023
Background/objectives: The most important risk factor for recurrent pancreatitis after an episode of acute alcoholic pancreatitis is continuation of alcohol use.
the Dutch Pancreatitis Study Group
core  

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé, Nicholas J. Bamford, Jonathan Elliott, Yu‐Mei Chang, Karen Rickards, Nicola J. Menzies‐Gow   +5 more
wiley   +1 more source

Hypertriglyceridemia and acute pancreatitis: clinical and basic research—a narrative review

Journal of Pancreatology
Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP), and the incidence of HTG-induced AP (HTG-AP) is rising worldwide as a result of changes in lifestyle and dietary habits.
Lin Gao, Weiqin Li
doaj   +1 more source

Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

Cells, 2020
Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics.
Michael Chvanov, Svetlana Voronina, Xiaoying Zhang, Svetlana Telnova, Robert Chard, Yulin Ouyang, Jane Armstrong, Helen Tanton, Muhammad Awais, Diane Latawiec, Robert Sutton, David N. Criddle, Alexei V. Tepikin   +12 more
doaj   +1 more source