Results 61 to 70 of about 183,025 (305)

Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care

American Journal of Hematology, EarlyView.
ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali, Grace Elsey, Kayla Fulginiti, Zanette Kanani‐Bradley, Holly R. Kubaney, Sandra Kurtin, Theresa Nguyen, Jennifer Turchina, Charlotte B. Wagner   +8 more
wiley   +1 more source

Chronic pancreatitis and pancreatic carcinoma [PDF]

Postgraduate Medical Journal, 1997
Summary The differential diagnosis between pancreatic cancer and chronic pancreatitis is very important as the management and prognosis of these two diseases is different. In most patients with pancreatic disease, the diagnosis can be established but there is a subgroup of patients in whom it is difficult to differentiate between these ...
J D, Evans, D G, Morton, J P, Neoptolemos   +2 more
openaire   +2 more sources

High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer

Frontiers in Immunology
BackgroundAminooctylamine (ANO1) plays an oncogenic role in various cancers. However. its role in pancreatic cancer (PC) has rarely been studied. This study investigated the prognostic value of ANO1 and its correlation with the tumor microenvironment ...
Guangnian Zhang, Zhihui Shu, Jun Yu, Jianshui Li, Pengsheng Yi, Bin Wu, Dawei Deng, Shu Yan, Yong Li, Dongmei Ren, Yifu Hou, Yifu Hou, Chuan Lan   +12 more
doaj   +1 more source

Time-Course Lipidomics of Ornithine-Induced Severe Acute Pancreatitis Model Reveals the Free Fatty Acids Centered Lipids Dysregulation Characteristics

Metabolites, 2023
The relationship between the type and intensities of lipids of blood and pancreas and the pathological changes in the pancreas during severe acute pancreatitis (SAP) remains unclear.
Jinxi Yang, Manjiangcuo Wang, Qi Qiu, Yan Huang, Yiqin Wang, Qianlun Pu, Na Jiang, Rui Wang, Li Wen, Xiaoying Zhang, Chenxia Han, Dan Du   +11 more
doaj   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

RAGE Signalling in Acute Inflammatory Disorders: Therapeutic Potential of Natural Products

Biomolecules
Acute inflammatory disorders, including acute lung injury, acute pancreatitis, ischaemia–reperfusion injury, and sepsis, are major clinical challenges characterised by rapid progression, a characteristic cytokine storm, and high mortality rates.
Qiqi Wang, Wenjuan Luo, Qihang Wan, Yuying Li, Diane Latawiec, Robert Sutton, John Windsor, Wei Huang, Peter Szatmary, Tingting Liu   +9 more
doaj   +1 more source

Hemoconcentration is associated with early faster fluid rate and increased risk of persistent organ failure in acute pancreatitis patients

JGH Open, 2020
Background Controversies existed surrounding the use of hematocrit to guide early fluid therapy in acute pancreatitis (AP). The association between hematocrit, early fluid therapy, and clinical outcomes in ward AP patients needs to be investigated ...
Tao Jin, Lan Li, Lihui Deng, Si Wen, Ruwen Zhang, Na Shi, Ping Zhu, Lan Lan, Ziqi Lin, Kun Jiang, Jia Guo, Tingting Liu, Anthony Philips, Xiaonan Yang, Vikesh K Singh, Robert Sutton, John A Windsor, Wei Huang, Qing Xia   +18 more
doaj   +1 more source

Identification of the nucleotide sequence of the lipoprotein lipase gene as well as its role in the development of hyperlipidemia and pancreatitis in the Miniature Schnauzer [PDF]

, 2005
Lipoprotein Lipase (LPL) is a key enzyme in lipid transport. It catalyses the hydrolysis of the triacylglycerol component of chylomicrons and very low-density lipoproteins (VLDL), providing non-esterified fatty acids for tissue utilization.
Schickel, Ralph
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

PANCREATIC LYMPHANGITIS AND CHRONIC PANCREATITIS [PDF]

JAMA: The Journal of the American Medical Association, 1913
The most important subject which is occupying the attention of abdominal surgeons to-day has to do with the elucidation of the pathogenesis, the recognition of the symptoms and the discovery of adequate means of treatment of the diseases of the pancreas.
openaire   +2 more sources