Results 231 to 240 of about 92,443 (271)

Atezolizumab, obinutuzumab and venetoclax for the treatment of patients with relapsed/refractory B non‐Hodgkin lymphoma: Final analysis of a phase II trial from the LYSA group

British Journal of Haematology, EarlyView.
Summary Developing new therapeutic regimens for relapsed/refractory (R/R) B non‐Hodgkin lymphoma (NHL) patients remains a significant unmet clinical need. Our objective was to evaluate atezolizumab (ATE), obinutuzumab (OBI) and venetoclax (VEN) combination in patients with R/R NHL who had received at least one prior anti‐CD20‐containing ...
Charles Herbaux, Emmanuel Bachy, Reda Bouabdallah, Stéphanie Guidez, Olivier Casasnovas, Pierre Feugier, Gandhi Damaj, Hervé Tilly, Loïc Ysebaert, Steven Le Gouill, Nadine Morineau, Emmanuel Gyan, Rémy Gressin, Roch Houot, Morgane Cheminant, Franck Morschhauser, Catherine Thieblemont, Corinne Haioun, Emmanuelle Nicolas‐Virelizier, Luc‐Matthieu Fornecker, Nicolas Daguindau, Guillaume Cartron   +21 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks

Cancer Science, EarlyView.
In this review, the authors first introduce genetic aberrations that cause cancer development. Then, they illustrate the impact of epigenetic abnormalities in cancer, especially with reference to studies that use in vivo reprogramming technologies. Finally, the authors discuss the importance of histological evaluations of tumor tissue to understand non‐
Yosuke Yamada, Nao Sankoda, Yasuhiro Yamada   +2 more
wiley   +1 more source

Excess mortality in people hospitalised for alcohol use disorders before and during the pandemic – A registry‐based retrospective cohort study

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The aim was to analyse mortality and estimate the life expectancy among people hospitalised for alcohol use disorders (AUD) compared with the general Czech population aged ≥20 years. A temporal perspective on excess mortality was used, covering three recent calendar periods before and during the pandemic.
Ladislav Kážmér, Ondřej Šíba, Barbora Orlíková   +2 more
wiley   +1 more source

Clinical performance of endoscopic ultrasound‐guided tissue acquisition for perivascular soft‐tissue cuffing suspected to be extravascular migratory metastases of pancreatic or bile duct cancer (with video)

Digestive Endoscopy, EarlyView.
Objectives This study aimed to investigate the diagnostic performance and safety of endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) for perivascular soft‐tissue cuffing (PSTC). Methods This single‐center, retrospective study evaluated patients in whom EUS‐TA was performed for PSTC in pancreatic or bile duct cancer lesions between October 2017 ...
Kosuke Maehara, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Daiki Yamashige, Kohei Okamoto, Daiki Agarie, Shin Yagi, Soma Fukuda, Masaru Kuwada, Yasuhiro Komori, Takehiko Koga, Atsushi Kanno, Tsunao Imamura, Yutaka Saito, Takuji Okusaka   +15 more
wiley   +1 more source

Verification in an animal study of the appropriate settings for a novel radiofrequency generator in radiofrequency ablation therapy for residual intraductal lesions after endoscopic papillectomy (with video)

Digestive Endoscopy, EarlyView.
Endoscopic intraductal radiofrequency ablation (ID‐RFA) can curatively treat residual intraductal lesions after endoscopic papillectomy. This study aimed to verify the tissue invasiveness of ID‐RFA using a novel RF generator and to explore its appropriate settings in an animal experiment, followed by a small clinical study.
Kenjiro Yamamoto, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kazumasa Nagai, Yukitoshi Matsunami, Hiroyuki Kojima, Hirohito Minami, Noriyuki Hirakawa, Kyoko Asano, Shuntaro Mukai   +12 more
wiley   +1 more source

Endoscopic management of primary sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has high sensitivity and specificity ...
Suguru Mizuno, Yoshihito Uchida, Satsuki Ando, Masamitsu Nakao, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida   +8 more
wiley   +1 more source

Endoscopic diagnosis of immunoglobulin G4‐related sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Immunoglobulin G4 (IgG4)‐related sclerosing cholangitis (IgG4‐SC) is a distinct form of sclerosing cholangitis frequently associated with autoimmune pancreatitis and is recognized as a biliary manifestation of IgG4‐related disease. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS) are key diagnostic modalities ...
Itaru Naitoh, Michihiro Yoshida, Takahiro Nakazawa   +2 more
wiley   +1 more source

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source

Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To investigate the associations of intra‐pancreatic fat deposition (IPFD) with very‐low‐density lipoprotein (VLDL), intermediate‐density lipoprotein (IDL) and lipoprotein lipase. Materials and methods A total of 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for the quantification of IPFD.
Yutong Liu, Loren Skudder‐Hill, Wandia Kimita, Xiatiguli Shamaitijiang, Ivana R. Sequeira‐Bisson, Maxim S. Petrov   +5 more
wiley   +1 more source