Results 1 to 10 of about 173,135 (267)

Electrochemical Detection of Drugs via a Supramolecular Cucurbit[7]uril-Based Indicator Displacement Assay. [PDF]

ACS Sens, 2023
Electrochemical detection methods are attractive for developing miniaturized, disposable, and portable sensors for molecular diagnostics. In this article, we present a cucurbit[7]uril-based chemosensor with an electrochemical signal readout for the ...
Kumar NM, Gruhs P, Casini A, Biedermann F, Moreno-Alcántar G, Picchetti P.   +5 more
europepmc   +3 more sources

Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats. [PDF]

J Physiol, 2023
Abstract figure legend In decerebrated rats, CRISPR‐induced functional knockout of TRPV1 channels had no effect on the magnitude of either the exercise pressor reflex evoked by static contraction of the triceps surae muscles or the muscle mechanoreflex evoked by calcaneal tendon stretch.
Anselmi L, Ducrocq GP, Ruiz-Velasco V, Stocker SD, Higgins SP, Kaufman MP.   +5 more
europepmc   +2 more sources

Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats. [PDF]

FASEB J, 2023
During exercise the brainstem integrates sensory information from skeletal muscle afferents and arterial baroreceptors, resulting in controlled increases in blood pressure. The influence of central insulin signaling on the exercise pressor reflex (EPR) is undetermined.
Estrada JA, Hotta N, Kim HK, Ishizawa R, Fukazawa A, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M.   +8 more
europepmc   +2 more sources

Alterations in neuromuscular junction morphology with ageing and endurance training modulate neuromuscular transmission and myofibre composition. [PDF]

J Physiol
Abstract figure legend The morphology and function of the neuromuscular junction (NMJ), the synapse connecting motor neurons and myofibres, change with ageing and exercise training. The age‐related decrease in the overlap between nerve terminal and acetylcholine receptors at the NMJ impaired neuromuscular transmission, as evidenced by the decrease in ...
Yamaguchi T, Kouzaki K, Sasaki K, Nakazato K.   +3 more
europepmc   +2 more sources

Pancuronium bromide in emergency surgery [PDF]

Anaesthesia, 1976
Pancuronium bromide, a steroid non-depolarising muscle relaxant has been used to assist intubation before emergency operations in 32 patients and has been found to be satisfactory for quick intubation in a dose of 0-1 mg per kg of body weight. There was no vomiting during induction.
S. C. Chatterjee, S. K. Chatterjee
openaire   +4 more sources

Evaluation of the effect of small single intravenous dose of amiodarone on the prevention of arrhythmias in patients who underwent coronary artery bypass graft surgery: A randomized controlled trial [PDF]

J Arrhythm
We demonstrated that the predictive properties in the administration of amiodarone 10 min before the declamping of the aorta can significantly lower the rates of arrhythmia after CABG, while also decreasing hospitalization duration. Abstract Background Atrial fibrillation (AF) is the most frequent arrhythmia after cardiac surgery causing a range of ...
Azemati S, Dehghanpisheh L, Vatankhah P, Khademi S, Ghazinour M, Eghdami S.   +5 more
europepmc   +2 more sources

Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs [PDF]

, 2012
Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods:
A. Pape, B. Zwissler, Barton RG, Cain SM, Eisenberg E, Fontana JL, H. Kertscho, Habler OP, Haller M, Herweling A, Holt JP, Ickx BE, Kampe S, Kemming GI, Kim J, Koskolou MD, Levy PS, M. Lossen, Madjdpour C, Marik PE, McCall M, Meier J, Meier JM, Meier JM, Meier JM, Meisner FG, Messmer KF, Muldoon SM, Naguib M, O. Habler, O. Horn, P. Stein, Pape A, Pape A, Pape A, Perez V, Pittman RN, Richardson RS, Russell WC, S. Kutschker, Schumacker PT, van der Linden P, van der Linden P, van Woerkens EC, Vernon DD, Werlhof V, Zollinger A   +46 more
core   +1 more source

Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY‐747 designed for the treatment of resistant hypertension

British Journal of Pharmacology, Volume 180, Issue 19, Page 2500-2513, October 2023., 2023
Abstract Background and Purpose First‐generation soluble guanylate cyclase (sGC) stimulators have shown clinical benefit in pulmonary hypertension (riociguat) and chronic heart failure (vericiguat). However, given the broad therapeutic opportunities for sGC stimulators, tailored molecules for distinct indications are required.
Frank Wunder, Johannes‐Peter Stasch, Andreas Knorr, Thomas Mondritzki, Damian Brockschnieder, Eva‐Maria Becker‐Pelster, Peter Sandner, Hanna Tinel, Gorden Redlich, Ingo V. Hartung, Alexandros Vakalopoulos, Markus Follmann   +11 more
wiley   +1 more source

The U.S. Supreme Court is about to re-evaluate how some states carry out lethal injections. [PDF]

, 1975
Next month, the Supreme Court will hear oral arguments in a case which challenges Oklahoma’s use of “liquid fire” in executions. The drug – potassium chloride – is one of a cocktail of drugs currently used in some states to carry out death sentences, a ...
Millar, Nancy E.
core   +3 more sources

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources