Results 61 to 70 of about 44,817 (277)

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

A prospective clinico-hematological study in 100 cases of pancytopenia in capital city of India

Journal of Applied Hematology, 2014
Context: Pancytopenia is not a disease but a clinico-hematological entity encountered in clinical practice. A prompt intervention is required to avoid complications, which can occur in these patients.
Sweta, Sumit Barik, Raj K Chandoke, Anand K Verma   +3 more
doaj   +1 more source

A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia

Apollo Medicine, 2022
Background: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in ...
Sanjaykumar Somsingbhai Rathwa, Darshankumar Manubhai Raval, Shashwat Mallik, Shahin Khan   +3 more
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Characterizing pancytopenia in a large Asian cohort of people living with HIV: A 23-year nested case-control study

Journal of Infection and Public Health
Background: Pancytopenia, a severe hematologic comorbidity, raises significant clinical concern for increased morbidity and mortality in people living with HIV (PLWH).
Xiangyi Shen, Xiaojing Song, Yanling Li, Xiaoxia Li, Lianfeng Lu, Xinmin Duan, Yang Han, Ling Luo, Huiting Liu, Wei Lv, Wei Cao, Taisheng Li   +11 more
doaj   +1 more source

Clinicoetiological profile of children with bicytopenia and pancytopenia

Pediatric Hematology Oncology Journal, 2023
Background: Bicytopenia, and pancytopenia have a wide etiological spectrum in children, ranging from viral infections to malignancies. There is limited data describing the clinicoetiological profile of bicytopenia and pancytopenia in children in recent ...
Arunendr Sharma, K. Rajeshwari, Deepak Kumar   +2 more
doaj   +1 more source

A Spectrum of Hematological Disorders in Children with Pancytopenia Based on Bone Marrow Examination in a Tertiary Care Hospital

Cureus, 2019
Introduction Pancytopenia is a common presentation in the pediatric population. It is a manifestation of various diseases, and its etiology can be explained on the basis of bone marrow examination.
Raana Zeeshan, Bilal Irshad, M. A. Aslam, M. T. Khan, Hamza Bhatti, N. Chaudhary   +5 more
semanticscholar   +1 more source

Reversible gelatinous transformation of bone marrow – A rare and reversible cause of pancytopenia in tuberculosis

Iraqi Journal of Hematology, 2023
A 68-year-old man presented with a low-grade fever for one month. He had loss of appetite and had lost 6 kilograms of weight in the last two months. He was evaluated and found to have miliary tuberculosis with pancytopenia.
Mansoor C Abdulla
doaj   +1 more source

Pediatric autoimmune gastritis: An international, multicentric study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Autoimmune gastritis (AIG) has been poorly described in childhood. We sought to identify the patterns of manifestations of pediatric AIG at onset and to describe its laboratory, clinical, and histopathological features. Methods This was a retrospective, longitudinal, multicenter, cohort study enrolling histologically proven AIG ...
Marco Vincenzo Lenti, Shamim Joudaki, Emanuela Miceli, Edith Lahner, Sara Massironi, Martina Votto, Amelia Licari, Silvia Maria Elena Caimmi, Matteo Bramuzzo, Grazia Di Leo, Marco Crocco, Federica Malerba, Ruggiero Francavilla, Paolo Lionetti, Patrizia Alvisi, Roberto Panceri, Giovanna Zuin, Vincenzo Villanacci, Jacopo Barp, Maurizio Fuoti, Salvatore Oliva, Marina Aloi, Manuela Distante, Amit Assa, Yogev Dotan, Arnaldo Amato, Claudio Romano, Annamaria Staiano, Erasmo Miele, Caterina Strisciuglio, Maria Teresa Fioretti, Fabiana Zingone, Mara Cananzi, Costantino De Giacomo, Giovanni Di Nardo, Andrea Quadrelli, Alessandro Vanoli, Marco Paulli, Bruno Annibale, Gianluigi Marseglia, Antonio Di Sabatino   +40 more
wiley   +1 more source