Results 91 to 100 of about 789,810 (224)

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Evaluating Supply Chain Resilience During Pandemic Using Agent-based Simulation [PDF]

arXiv
Recent pandemics have highlighted vulnerabilities in our global economic systems, especially supply chains. Possible future pandemic raises a dilemma for businesses owners between short-term profitability and long-term supply chain resilience planning.
arxiv  

Improving Adult Vision Through Pathway‐Specific Training in Augmented Reality

Advanced Science, EarlyView.
Traditional perceptual training approaches are limited by stimulus specificity, treatment efficacy, and patient compliance. A novel altered reality (AR) method is developed to enhance pathway‐specific functions in human adults while performing everyday activities.
Yige Gao, Yulian Zhou, Qing He, Wen Wen, Peng Zhang   +4 more
wiley   +1 more source

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

npj Vaccines
DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared.
Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang   +21 more
doaj   +1 more source

Optimising Clinical Epidemiology in Disease Outbreaks: Analysis of ISARIC-WHO COVID-19 Case Report Form Utilisation

Epidemiologia
Standardised forms for capturing clinical data promote consistency in data collection and analysis across research sites, enabling faster, higher-quality evidence generation. ISARIC and the World Health Organization have developed case report forms (CRFs)
Laura Merson, Sara Duque, Esteban Garcia-Gallo, Trokon Omarley Yeabah, Jamie Rylance, Janet Diaz, Antoine Flahault, ISARIC Clinical Characterisation Group   +7 more
doaj   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Addressing the mental health impacts of COVID-19 on Canada’s frontline workers

Journal of Community Safety and Well-Being, 2023
Alexandra Heber, Amber Schick, Elizabeth Bose   +2 more
doaj   +1 more source

Verifying the Unique Charge Migration Pathway in Polymeric Homojunctions for Artificial Photosynthesis of Hydrogen Peroxide

Advanced Science, EarlyView.
Limited charge separation is a challenge for efficient photocatalysis. This work introduces a polymeric S‐scheme homojunction for unique charge separation and transfer in photocatalytic H2O2 production. Abstract Artificial photosynthesis for producing high‐value hydrogen peroxide (H2O2) using carbon nitride‐based systems holds immense potential ...
Qiang Cheng, Jingping Li, Yuxin Huang, Xiufan Liu, Biao Zhou, Qiao Xiong, Kai Wang   +6 more
wiley   +1 more source

A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
The ssLAMP method amplifies the nucleic acid of pathogen and identifies SNP mutations. By combining the portable detection device with smartphone‐based analysis software, enables rapid, on‐site SNP detection and genotyping of SARS‐Cov‐2 Omicron variants, providing a cost‐effective and field‐deployable solution for precise pathogen identification in ...
Qijie Lin, Hongchao Gou, Xiaoyun Qu, Kaiyuan Jia, Yuhui Deng, Dan Li, Qianyi Cai, Yucen Liang, Xiaozhen Xu, Yanbin Li, Jianhan Lin, Letian Li, Yuhang Jiang, Shouwen Du, Lingcong Deng, Bailing Yan, Ruidong Liu, Chang Li, Jianmin Zhang, Ming Liao   +19 more
wiley   +1 more source

Sustainable decision making for chemical process systems via dimensionality reduction of many objective problems

AIChE Journal, Volume 69, Issue 2, February 2023., 2023
Abstract Recent global events and the rise of sustainable investing have made clear that the chemical and energy industry must consider sustainability goals beyond profit maximization to remain competitive. Multiobjective optimization provides an ideal framework for analyzing sustainability tradeoffs, but when four or more objectives are considered ...
Justin M. Russell, Andrew Allman
wiley   +1 more source