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Infection, 2022
Pending approval of new antimicrobials, synergistic combinations are the only treatment option against pandrug-resistant A. baumannii (PDRAB). Considering the lack of a standardized methodology, the aim of this manuscript is to systematically review the methodology and discuss unique considerations for assessing antimicrobial combinations against PDRAB.
Stamatis Karakonstantis +2 more
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Pending approval of new antimicrobials, synergistic combinations are the only treatment option against pandrug-resistant A. baumannii (PDRAB). Considering the lack of a standardized methodology, the aim of this manuscript is to systematically review the methodology and discuss unique considerations for assessing antimicrobial combinations against PDRAB.
Stamatis Karakonstantis +2 more
openaire +2 more sources
Clinical treatment of pandrug-resistant bacterial infection consulted by clinical pharmacist
Saudi Pharmaceutical Journal, 2015 Pandrug-resistant (PDR) bacterial infections are associated with considerable prolongation of hospitalization and mortality in clinical practice.This case-series study was conducted during a 3-year period from 2011 to 2013. A total of 30 PDR patients consulted by clinical pharmacist were recorded to evaluate the anti-infection treatment.All isolates of
Zhi-Wen, Yang +3 more
exaly +3 more sources
Pandrug-resistant Klebsiella pneumoniae isolated from Ukrainian war victims are hypervirulent
Journal of InfectionCarbapenem- and colistin-resistant Klebsiella pneumoniae were isolated from war victims treated in hospitals in Ukraine. The question was whether these pandrug-resistant K. pneumoniae are pathogenic and capable of causing disease in a broader context.Klebsiella pneumoniae clinical isolates (n = 37) were tested for antibiotic resistance and subjected to
Michał Magda +2 more
exaly +3 more sources
Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?
International Journal of Antimicrobial Agents, 2007The evolving problem of antimicrobial resistance in Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae has led to the emergence of clinical isolates susceptible to only one class of antimicrobial agents and eventually to pandrug-resistant (PDR) isolates, i.e. resistant to all available antibiotics.
Matthew E Falagas, Ioannis A Bliziotis
exaly +3 more sources
Genomic path to pandrug resistance in a clinical isolate of Klebsiella pneumoniae
International Journal of Antimicrobial Agents, 2018Carbapenem-resistant Klebsiella pneumoniae have spread globally throughout tertiary hospitals. Many Carbapenem-resistant K. pneumoniae clinical isolates are multidrug-resistant (MDR) and may become eventually pandrug-resistant (PDR). Here we present the closed genome of a PDR VIM-1-producing K. pneumoniae strain (KP1050) obtained in a tertiary hospital.
Fernando Lázaro-Perona +5 more
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Extremely and pandrug-resistant bacteria extra-deaths: myth or reality?
European Journal of Clinical Microbiology & Infectious Diseases, 2018In 2009, the European Centre for Disease Prevention and Control (ECDC) estimated that multidrug-resistant (MDR) bacterial infections were responsible for 25,000 extra-deaths per year. In 2015, another report estimated that 12,500 extra-deaths were attributable to MDR bacteria every year in France. Recently, the United Nations claimed that resistance to
Abat, Cedric +4 more
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Survival of extensively- and pandrug-resistant isolates of Acinetobacter baumannii in soils
Applied Soil Ecology, 2020The extensively- and pandrug-resistant isolates of Acinetobacter baumannii are a leading cause of hospital acquired infections. Aside from reports of A. baumannii in wastewaters influenced by hospital effluents, only two studies reported its detection in soils. The lack of data hinders the assessment of soil as the possible environmental reservoir of A.
Svjetlana Dekić +2 more
exaly +3 more sources
[Mechanisms of pandrug-resistance of Pseudomonas aeruginosa].
Zhonghua yi xue za zhi, 2009To explore the mechanisms of pandrug-resistance (PDR) of Pseudomonas aeruginosa (PA).Nineteen strains of PA were collected from Huashan Hospital, Shanghai. Agar dilution method was used to detect the levels of minimum inhibitory concentration (MIC) of 14 antimicrobial drugs to the PA strains.
Ji-lu, Shen, De-mei, Zhu, Ming-gui, Wang
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008
Melioidosis has recently gained the status of an emerging disease in India. Multidrug-resistant (MDR) Gram-negative bacteria, however, are already responsible for treatment failure and mortality. In addition, pandrug-resistant (PDR) Gram-negative bacteria have emerged as a new threat to modern medicine. The treatment, clinical follow up, and outcome of
Chiranjay, Mukhopadhyay +5 more
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Melioidosis has recently gained the status of an emerging disease in India. Multidrug-resistant (MDR) Gram-negative bacteria, however, are already responsible for treatment failure and mortality. In addition, pandrug-resistant (PDR) Gram-negative bacteria have emerged as a new threat to modern medicine. The treatment, clinical follow up, and outcome of
Chiranjay, Mukhopadhyay +5 more
openaire +2 more sources
Molecular characterisation of clinical pandrug-resistant Alcaligenes faecalis strain MUB14
International Journal of Antimicrobial Agents, 2020Piotr Majewski +8 more
openaire +2 more sources