Results 101 to 110 of about 3,038,457 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

February Oversight Report

, 2009
February report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the valuation of the U.S. Treasury's policy of investing capital in financial institutions through the Troubles Asset Relief Program (TARP)
United States. Congressional Oversight Panel.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

High-yield Micro-LED laser transfer accomplished using an ablation-type release material

APL Materials
Micro light-emitting diode (Micro-LED) is a highly promising technology in the field of new displays, with the mass transfer process involved in its manufacturing process widely regarded as a major barrier to their further development.
Yujie Xie, Xin Lin, Taifu Lang, Xiaowei Huang, Xuehuang Tang, Shuaishuai Wang, Chang Lin, Kaixin Zhang, Jie Sun, Qun Yan   +9 more
doaj   +1 more source

Biocomposite of banana fiber, peanut shells from Manabí (Ecuador) and recycled expanded polystyrene

Revista Hábitat Sustentable
This research involves the development of a thermoplastic polymer biocomposite in a matrix of recycled expanded polystyrene reinforced with banana pseudostem fiber and crushed peanut shells.
Eddie Efrén Echeverría-Maggi, Vicente Flores-Alés, Juan Jesús Martín-del-Río   +2 more
doaj   +1 more source

January Oversight Report

, 2011
January report of the U.S. Congressional Oversight Panel describing their activities and findings regarding government intervention in the domestic automotive industry through the financial assistance provided by the Troubled Asset Relief Program ...
United States. Congressional Oversight Panel.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Patient-identified priorities for a mental health program tailored to premenstrual dysphoric disorder

Women's Health
Background: There are no mental health programs tailored to premenstrual dysphoric disorder (PMDD). Objectives: Examine the content and features that PMDD patients desire in a mental health program. Design: Anonymous online survey.
Sneha Chenji, Christine Bueno, May Ly, Sandi MacDonald, Rebekka Chartier, Catherine Lunn, Jennifer L. Gordon   +6 more
doaj   +1 more source

November Oversight Report

, 2010
November report of the U.S. Congressional Oversight Panel describing their activities and findings regarding mortgage document irregularities, including sections on background information, legal consequences, litigation, and the impact on banks and the ...
United States. Congressional Oversight Panel.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source