Results 91 to 100 of about 5,913,777 (355)

Experiences from youth advisors in chronic disease prevention research

Research Involvement and Engagement
Engaging young people in research is a promising approach to tackling issues like chronic disease prevention. Our involvement as youth advisors provided valuable experiences, including being at the forefront of change and learning to work within a ...
Dominik Mautner, Radhika Valanju, Imeelya Al Hadaya, Meera Barani, Alexi Cross, Emily McMahon, Bowen Ren, Dominique Rose, Aviral Sharda, Alexander Sinnett, Fulin Yan, Sara Wardak   +11 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Application of distorted models in developing scaled structural models [PDF]

, 1967
In the design and development of dynamically similar structural models a distorted model of the panel is used. The panel thickness is made larger than that dictated by geometric scaling, and the mass of the panel is decreased by adding mass to the ...
White, R. W.
core   +1 more source

Panel Discussion [PDF]

, 1993
Misrock, S. Leslie, Richards, John, Wegner, Harold C.   +2 more
core   +10 more sources

A switchable multifunctional artificial neuron with rate coding and time‐to‐first‐spike coding for accurate image recognition

FlexMat
Inspired by the structure and principles of the human brain, the development of artificial neurons for spiking neural network (SNN) has been stimulated.
Weiqi Liu, Chenhui Xu, Weidong Xie, Jiabin Ye, Zhiwei Zhu, Zhenyuan Lin, Huipeng Chen   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

On the treatment of repeated observations in panel data: efficiency of mixed logit parameter estimates [PDF]

, 2011
Travel demand models are often estimated using cross-sectional data. Although the use of panel data has recently increased in many areas, there are still many aspects that have not been analyzed fully.
Cherchi, E., Heydecker, B.G., Ortúzar, J.d.-D., Yáñez, M.F.   +3 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Toward grouped-reservoir computing: organic neuromorphic vertical transistor with distributed reservoir states for efficient recognition and prediction

Nature Communications
Reservoir computing has attracted considerable attention due to its low training cost. However, existing neuromorphic hardware, focusing mainly on shallow-reservoir computing, faces challenges in providing adequate spatial and temporal scales ...
Changsong Gao, Di Liu, Chenhui Xu, Weidong Xie, Xianghong Zhang, Junhua Bai, Zhixian Lin, Cheng Zhang, Yuanyuan Hu, Tailiang Guo, Huipeng Chen   +10 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source