Results 71 to 80 of about 1,872,327 (265)

THE SAVINGS-TRADE-FISCAL GAP MODEL: APPLICATION IN SELECTED WEST AFRICAN STATES

Studies and Scientific Researches: Economics Edition, 2017
With most African economies experiencing adverse economic misalignment in recent times, the need of enhancing the growth process cannot be overemphasized.
Efayena Oba Obukohwo, Buzugbe Patricia Ngozi   +1 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Screening for Preterm Birth: Potential for a Metabolomics Biomarker Panel

Metabolites, 2019
The aim of this preliminary study was to investigate the potential of maternal serum to provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth (SPTB) in asymptomatic pregnant women at 15 and/or 20 weeks’ gestation.
Elizabeth C. Considine, Ali S. Khashan, Louise C. Kenny   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Toward Enhanced Biomimetic Artificial Visual Systems Based on Organic Heterojunction Optoelectronic Synaptic Transistors

Advanced Electronic Materials
Artificial visual systems, inspired by the human eye, hold significant potential in artificial intelligence. Optoelectronic synapses, integrating image perception, processing, and memory in a single device, offer promising solutions.
Haonan Wang, Wandi Chen, Wenjuan Su, Zhenyou Zou, Shuchen Weng, Xiongtu Zhou, Chaoxing Wu, Tailiang Guo, Yongai Zhang   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cross-layer transmission realized by light-emitting memristor for constructing ultra-deep neural network with transfer learning ability

Nature Communications
Deep neural networks have revolutionized several domains, including autonomous driving, cancer detection, and drug design, and are the foundation for massive artificial intelligence models.
Zhenjia Chen, Zhenyuan Lin, Ji Yang, Cong Chen, Di Liu, Liuting Shan, Yuanyuan Hu, Tailiang Guo, Huipeng Chen   +8 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Experiences from youth advisors in chronic disease prevention research

Research Involvement and Engagement
Engaging young people in research is a promising approach to tackling issues like chronic disease prevention. Our involvement as youth advisors provided valuable experiences, including being at the forefront of change and learning to work within a ...
Dominik Mautner, Radhika Valanju, Imeelya Al Hadaya, Meera Barani, Alexi Cross, Emily McMahon, Bowen Ren, Dominique Rose, Aviral Sharda, Alexander Sinnett, Fulin Yan, Sara Wardak   +11 more
doaj   +1 more source