Results 51 to 60 of about 3,038,457 (311)

September Oversight Report [PDF]

open access: yes, 2010
September report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the results of the Treasury's Troubled Asset Relief Program(TARP) in mitigating the effects of the 2007 financial ...
United States. Congressional Oversight Panel.
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

January Oversight Report

open access: yes, 2009
January report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the U.S.
United States. Congressional Oversight Panel.
core   +1 more source

Towards mixed physical node reservoir computing: light-emitting synaptic reservoir system with dual photoelectric output

open access: yesLight: Science & Applications
Memristor-based physical reservoir computing holds significant potential for efficiently processing complex spatiotemporal data, which is crucial for advancing artificial intelligence.
Minrui Lian   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Developing and Understanding Olfactory Evaluation of Boar Taint

open access: yesAnimals, 2020
Trained expert panels are used routinely in boar taint research, with varying protocols for training of panelists and scoring methods. We describe a standardized process for training and scoring, to contribute to standardize the olfactory detection of ...
Evert Heyrman   +7 more
doaj   +1 more source

The First Report of the Congressional Oversight Panel for Economic Stabilization

open access: yes, 2008
December report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the U.S.
United States. Congressional Oversight Panel.
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

July Oversight Report

open access: yes, 2009
July report of the U.S. Congressional Oversight Panel describing their activities and findings regarding farm loan restructuring, including sections on agriculture markets, and farm credit ...
United States. Congressional Oversight Panel.
core  

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