Results 141 to 150 of about 4,501,132 (351)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Development of a panel dataset from the IAB Establishment Panel cross-sectional data [PDF]

open access: yes
"The IAB Establishment Panel now consists of 12 waves from 1993-2004, which are available for research use in the Research Data Centre of the Federal Employment Agency at the Institute for Employment Research.
Alda, Holger   +3 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Most recent changepoint detection in Panel data [PDF]

open access: green, 2016
Lawrence Bardwell   +4 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

A DESIGUALDADE DE RENDA E A EDUCAÇÃO PODEM EXPLICAR A CRIMINALIDADE?: uma análise para os estados brasileiros

open access: yesRevista de Políticas Públicas, 2014
This study aims to understand the Economics of Crime, an issue very relevant today in Brazilian states. From theoretical and empirical research and test, it will analyze the hypothesis that the homicide rate is positively related to the level of income ...
Renata Costa de Carvalho   +1 more
doaj  

GMM Estimation of Dynamic Panel Data Models with Persistent Data [PDF]

open access: yes
This paper considers GMM based estimation and testing procedures for two versions of the AR(1) model with Fixed Effects, henceforth abbreviated as ARFE(1): the conditional ARFE(1) model, and the inclusive ARFE(1) model, which contains the stationary ARFE(
Hugo Kruiniger
core  

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