Results 71 to 80 of about 1,575,835 (313)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Panel data offer a valuable lens through which social science phenomena can be examined over time. With panel data, we can overcome some of the fundamental problems with conventional cross-sectional analyses by focusing on the within-unit changes rather than the differences between units.
Tobias Rüttenauer, Nicole Kapelle
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Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The impact of remittances on economic growth: An econometric model
EconomiA, 2017 Remittances in the world represent one of major international financial resources, which sometimes they exceed the flows of foreign direct investment (FDI).
Dietmar Meyer, Adela Shera
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Nonlinear Panel Data Models [PDF]
, 2008 Panel or longitudinal data are becoming increasingly popular in applied work as they offer a number of advantages over pure cross-sectional or pure time-series data. A particularly useful feature is that they allow researchers to model unobserved heterogeneity at the level of the observational unit, where the latter may be an individual, a household, a
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Revista Finanzas y Política Económica, 2016 This article examines inconsistencies in the assumptions on which the new macroeconomic consensus is based, before going on to propose an alternative theoretical framework for understanding how exchange rate interventions work, and the compensatory ...
Eduardo Rosas Rojas
doaj
Allocentrism and numerator-based innovation: Panel data evidence
International Journal of Innovation StudiesWe explore the existence of a relationship between firms' allocentric approach, measured by their collaboration activities for innovation, and the orientation of their innovation.
Pedro Mendi, Alejandro Ruelas-Gossi
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