Results 251 to 260 of about 509,644 (312)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

From risk factors to molecular targets: clinical associations and molecular docking insights into phthalate-associated diabetic retinopathy. [PDF]

Front Med (Lausanne)
Xu Z, Bai S, He C, Lv X, Li Q, Mao Q, Wu H, Wang P.   +7 more
europepmc   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

A multicenter, clinically interpretable prediction model for malignancy risk in C-TIRADS 3-4 thyroid nodules. [PDF]

Front Oncol
Liu W, Xie Q, Liu C, Chen B, Yang X, Yang L, Yu H.   +6 more
europepmc   +1 more source

Panel data analysis with regression trees

Journal of the Korean Data and Information Science Society, 2014
openaire   +2 more sources

Identification of succinylation-related genes in bladder cancer: integration of single-cell and transcriptomic data. [PDF]

Front Immunol
Yang J, You Z, Mo H, Pu J, Shen G, Miao Z.   +5 more
europepmc   +1 more source