Results 61 to 70 of about 553,821 (338)

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure

European Journal of Psychotraumatology
Background: PTSD is comorbid with a number of other mental health difficulties and the link between voice hearing and PTSD has been explored in adult samples.Objective: To compare the trauma history, symptomatology, and cognitive phenotypes of children ...
Katie Lofthouse, Ella Beeson, Tim Dalgleish, Andrea Danese, Joanne Hodgekins, Gerwyn Mahoney-Davies, Patrick Smith, Paul Stallard, Jon Wilson, Richard Meiser-Stedman   +9 more
doaj   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

α1 Adrenergic Receptors Mediate Panic-like Defensive Behavior in Alcohol-Drinking but Not Alcohol-Naïve Rats

Pharmaceuticals
Background: Most animals display different defensive behavioral strategies during imminent or potential threats. These responses are relevant for understanding human behavioral disorders.
Thatiane De Oliveira Sergio, Jacob Kellner, Sarah Wean, Frederic W. Hopf   +3 more
doaj   +1 more source

Hormonal response during a fenfluramine-associated panic attack

Brazilian Journal of Medical and Biological Research, 1997
Secretion curves for prolactin, cortisol, TSH, and GH from a 37-year old woman with dysthymia and panic disorder with agoraphobia were determined one day prior to (day I), and during a panic attack (day II) associated with an oral dose of 60 mg dl ...
A.H.G. Vieira, R.T. Ramos, V. Gentil
doaj   +1 more source

Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options

Frontiers in Psychiatry, 2020
Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of disability. While there continues to be expansive research in posttraumatic stress disorder (PTSD), depression and schizophrenia, there is a relative dearth of novel ...
Amir Garakani, Amir Garakani, Amir Garakani, James W. Murrough, James W. Murrough, Rafael C. Freire, Robyn P. Thom, Kaitlyn Larkin, Frank D. Buono, Dan V. Iosifescu, Dan V. Iosifescu   +10 more
doaj   +1 more source

Characterization of superspreaders movement in a bidirectional corridor using a social force model

Frontiers in Public Health, 2023
During infectious disease outbreaks, some infected individuals may spread the disease widely and amplify risks in the community. People whose daily activities bring them in close proximity to many others can unknowingly become superspreaders.
Dramane Sam Idris Kanté, Dramane Sam Idris Kanté, Aissam Jebrane, Abdelilah Hakim, Adnane Boukamel   +4 more
doaj   +1 more source

An Analysis of COVID-19 Lock-Down Panic Buying Motivators Among Undergraduate Students [PDF]

, 2022
Natalia Urrutia-Alvarez, Alexis Theriot, Erin McKinley   +2 more
openalex   +1 more source

Acid–base dysregulation and chemosensory mechanisms in panic disorder: a translational update

Translational Psychiatry, 2015
Panic disorder (PD), a complex anxiety disorder characterized by recurrent panic attacks, represents a poorly understood psychiatric condition which is associated with significant morbidity and an increased risk of suicide attempts and completed suicide.
Lauren L. Vollmer, J. Strawn, J. Strawn, R. Sah   +3 more
semanticscholar   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source