Results 81 to 90 of about 62,417 (242)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

A fobia e o pânico em suas relações com a angústia

Psicologia: Teoria e Pesquisa
Nesse texto, objetivou-se indicar as relações da angústia com as manifestações patológicas da fobia e do pânico, demonstrando a adequação da proposta de intervenção terapêutica, dentro de uma perspectiva psicanalítica.
Vera Lopes Besset, Kátia Kac Nigri, Leonardo Pinto de Almeida   +2 more
doaj   +1 more source

Unsupervised machine learning for multi‐system adverse event pattern detection in pharmacovigilance: A proof‐of‐concept analysis of fluoroquinolone reports in FAERS

British Journal of Clinical Pharmacology, EarlyView.
. Aims Traditional pharmacovigilance detects single drug–event associations but cannot readily characterize multi‐system adverse‐event patterns such as fluoroquinolone‐associated disability. We evaluated unsupervised machine learning for this purpose, using fluoroquinolones as an exemplar.
Niaz Chalabianloo, Sheikh S. Abdullah, Kamran Sedig, Flory T. Muanda   +3 more
wiley   +1 more source

Evolution of COVID-19 Impact on Russian Stock Market: Panic Effect

Финансы: теория и практика
Over the past few years, many research papers have referred to stock market volatility in relation to investor attention and sentiment and our article adds to the current literature on financial market reactions to the economic consequences of COVID-19 ...
Yu. V. Egorova, A. A. Nepp, I. I. Tishchenko   +2 more
doaj   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Tapu-gogy: Confining profane pedagogy to a new sacredness beyond the educator’s reach

JPHE
This paper is situated around a small exhibition installed in the classics museum of the author’s institution, called Tapu-gogy, in November and December 2022.
Vincent Olsen-Reeder
doaj   +1 more source

Misuse of obesity drugs exposes patients to serious and preventable harms: A French nationwide pharmacovigilance case series

British Journal of Clinical Pharmacology, EarlyView.
Introduction The rapid uptake of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) for obesity has been accompanied by increasing use outside approved indications and medical supervision. Evidence regarding the harms associated with such misuse remains limited because these situations are not captured in clinical trials and are difficult to ...
Jean‐Luc Faillie
wiley   +1 more source

Understanding Abstract Wonderment: The Reflections of a Novice Researcher

Grounded Theory Review: An International Journal, 2016
The aim of this paper is to present a novice researcher’s understanding of Glaser’s dictum to approach classical grounded theory studies with a sense of abstract wonderment.
Damian Stoupe
doaj  

Reception Baseline Assessment and ‘small acts’ of micro‐resistance

British Educational Research Journal, EarlyView.
Abstract In September 2021, following the global COVID‐19 pandemic, the Department for Education introduced a national standardised digital Reception Baseline Assessment (RBA) for all English 4‐year‐old children. We analyse RBA and its associated Quality Monitoring Visits, as a further intensification of the new public management of early years ...
Guy Roberts‐Holmes, Diana Sousa, Siew Fung Lee   +2 more
wiley   +1 more source

International student agency in academic self‐formation: Mobility as agency situated within knowledge structures

British Educational Research Journal, EarlyView.
Abstract With growing attention to student agency in academic and policy discourse, international education has become a prominent context for examining how students navigate new cultural, academic, linguistic and social environments. However, much of this discussion attributes student agency to the ‘international’ aspect, while overlooking the ...
Soyoung Lee
wiley   +1 more source