Results 61 to 70 of about 9,574 (196)

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez   +2 more
wiley   +1 more source

Transient bilateral brainstem dysfunction caused by topical administration of papaverine

, 2011
Papaverine has been associated with transient cranial nerve dysfunction after topical application during craniotomy. The authors report similar dysfunction after the use of papaverine affected brainstem structures.
Colleen M. Moran, Keith Peters, Christoph N. Seubert, Michael E. Mahla, Stephen Lewis, Brett Reichwage   +5 more
core   +1 more source

Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations

Molecules
Cisplatin is a potent compound in anti-tumor chemotherapy; however, its clinical utility is hampered by dose-limiting nephrotoxicity. This study investigated whether papaverine could mitigate cisplatin-induced kidney damage while preserving its ...
Shimaa A. Abass, Abdullah A. Elgazar, Sanad S. El-kholy, Amal I. El-Refaiy, Reem A. Nawaya, Mashooq Ahmad Bhat, Foad A. Farrag, Abdelrahman Hamdi, Marwa Balaha, Mohammed A. El-Magd   +9 more
doaj   +1 more source

Tadalafil versus Papaverine in Pharmaco Penile Duplex Ultrasonography-A Comparative Study [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: ‘Erectile Dysfunction’ (ED) traditionally defined as inability to achieve and/or maintain an erection for satisfactory sexual intercourse. It can affect men of all age groups, but prevalence increases with age.
Phani Chakravarty Mutnuru, Rahul Devraj, Harshavardhana Kuruba Ramanjaneyulu, Ramakrishna Narayanan, Rammurti Susarla, Jyotsna Yarlagadda   +5 more
doaj   +1 more source

A Golgi‐localized N‐methyltransferase and reversible aldo–keto reductases coordinate dual terminal routes in galanthamine biosynthesis

The Plant Journal, Volume 126, Issue 6, June 2026.
Significant Statement This study identifies LaTMT2, a Golgi‐localized N‐methyltransferase, and three reversible aldo–keto reductases (LaAKR1 and LaAKR3) as key enzymes coordinating the dual terminal routes of galanthamine biosynthesis in Leucojum aestivum.
Basanta Lamichhane, Archana Niraula, Natacha Merindol, Sarah‐Eve Gélinas, Patrick Lagüe, Simon Ricard, Hugo Germain, Isabel Desgagné‐Penix   +7 more
wiley   +1 more source

Effect of intraurethral papaverine on penile erection in rats

, 2004
Objectives: The aim of this study is to investigate erectile response to intraurethral administration of papaverine in rats. Material and methods: Male Sprague-Dawley rats were used in this study.

core   +1 more source

Systematic Review and Meta‐Analysis of the Prevalence of Substance Use Among Adolescents in South Africa

Drug and Alcohol Review, Volume 45, Issue 4, May 2026.
ABSTRACT Introduction Substance use among young people is a growing public health concern in South Africa (SA), with implications for short‐ and long‐term mental health, education and development. A lack of use data is among several challenges impeding progress to support young people.
Carrie Brooke‐Sumner, Lauro Estivalete Marchionatti, Zeina Mneimneh, Nadine Harker, Catherine O. Egbe, Dan Jenkins, Noluthando Mpisane, Meghan Mosalisa, Yeukai Chideya, Nuhaa Holland, Lesley‐Ann Erasmus‐Claassen, Giovanni Salum, Jason Bantjes   +12 more
wiley   +1 more source

Voltammetric determination of papaverine and drotaverine

, 2020
Isoquinoline derivatives (papaverine and drotaverine) are oxidized at a graphite electrode in a 0.1 M sulfuric acid solution to give voltammetric waves at 1.1 V for papaverine and at 1.05 and 1.28 V for drotaverine.
Samigullin A., Budnikov G., Ziyatdinova G.   +2 more
core  

The photochemistry of papaverine N-oxide

, 1973
Ultraviolet irradiation of papaverine N-oxide (2) in methanol gave papaverine (1) and 6,7-dimethoxy-2-(3',4'-dimethoxybenzyl)isocarbostyril (3). Irradiation of (2) in acetone resulted in the isolation of 7,8-dimethoxy-2-(3',4'-dimethoxybenzyl)-l,3-benz ...
JB Bremner, P Wiriyachitra
core   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1162-1180, May 2026.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source