Results 61 to 70 of about 26,987,137 (296)
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Microfluidic Paper-Based Analytical Devices: from Pocket to Paper-Based Elisa
Bioanalysis, 2011 Microfluidic paper-based analytical devices (microPADs) began as a simple idea with an ambitious goal. The idea was to make microfluidic devices out of paper instead of plas tic or glass. The goal was to develop low-cost and portable paper-based diagnostic devices to improve healthcare in developing countries.
openaire +4 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Materials Today BioIn clinical, critical bone defects are often treated with molded bone implants, yet they are prone to loosening, shape mismatch with the defect, and infection and inflammation.
Shanshan Li +7 more
doaj +1 more source
Integration of Paper Based Electro-Osmotic Pumps to Continuous Microfluidic Channels
Proceedings, 2018 This work reports for the first-time integration of continuous microfluidic channels to the paper-based electro-osmotic pumps (EOPs) with liquid bridges.
Kerem Kaya +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
AggregateAggregation‐induced emission (AIE) is a powerful route to amplify weakly emissive metal nanoclusters, yet simultaneously achieving AIE, structural precision, and ink compatibility remains challenging. Here, we demonstrate an aldehyde‐functional cellulose
Zijun Zhang, Jinpeng Li, Kefu Chen
doaj +1 more source
Paper‐Based Microfluidics for Electrochemical Applications
ChemElectroChem, 2019 AbstractPaper‐based microfluidics is characteristic of fluid transportation through spontaneous capillary action of paper and has exhibited great promise for a variety of applications especially for sensing. Furthermore, paper‐based microfluidics enables the design of miniaturized electrochemical devices to be applied in the energy sector, which is ...
Liu‐Liu Shen +2 more
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Paper-Based Synthetic Gene Networks [PDF]
Cell, 2014 Synthetic gene networks have wide-ranging uses in reprogramming and rewiring organisms. To date, there has not been a way to harness the vast potential of these networks beyond the constraints of a laboratory or in vivo environment. Here, we present an in vitro paper-based platform that provides an alternate, versatile venue for synthetic biologists to
Pardee, Keith +6 more
openaire +2 more sources