Results 31 to 40 of about 470,914 (259)

Porous Cellulose Substrate Study to Improve the Performance of Diffusion-Based Ionic Strength Sensors

Membranes, 2022
Microfluidic paper-based analytical devices (µPADs) are leading the field of low-cost, quantitative in-situ assays. However, understanding the flow behavior in cellulose-based membranes to achieve an accurate and rapid response has remained a challenge ...
Hamid Khosravi, Pouya Mehrdel, Joan Antoni López Martínez, Jasmina Casals-Terré   +3 more
doaj   +1 more source

Paper-Based Device for the Colorimetric Determination of Glucose in Whole-Blood Samples Using a Smartphone

Bioengineering
In many clinical settings, there is a great need for rapid, simple, and reliable diagnostic tools for the detection and quantification of various biomarkers.
Lara B. A. Boga, Katia Gianni, Mariano N. Aleman, Marcos S. Almiron Arroyo, Rossana E. Madrid   +4 more
doaj   +1 more source

Gradient hydrogels based on photo-initiated polymerization-induced self-assembly

Giant
Gradient materials enable performance optimization by adjusting composition or structure across one or more dimensions while minimizing interfacial incompatibility.
Yingchu Zhou, Ziqi Liu, Yi Zeng, Li Luo, Jie Chen, Diyuan Zheng, Zhao Wu, Chao Lang   +7 more
doaj   +1 more source

Quasi-one-dimensional enaminone-linked covalent organic frameworks for efficient CO₂ photoreduction

Nature Communications
Quasi-one-dimensional covalent organic frameworks have emerged as promising platforms for photochemical energy conversion due to their low density of basal sites, abundant edge sites, and dual-chain-like structure.
Junxian Bai, Yuxin Hu, Fangyuan Si, Yan Li, Guijie Liang, Tingting Hou, Yingwei Li   +6 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Characterization of Reagent Pencils for Deposition of Reagents onto Paper-Based Microfluidic Devices

Micromachines, 2017
Reagent pencils allow for solvent-free deposition of reagents onto paper-based microfluidic devices. The pencils are portable, easy to use, extend the shelf-life of reagents, and offer a platform for customizing diagnostic devices at the point of care ...
Cheyenne H. Liu, Isabelle C. Noxon, Leah E. Cuellar, Amanda L. Thraen, Chad E. Immoos, Andres W. Martinez, Philip J. Costanzo   +6 more
doaj   +1 more source

Advancement in Paper-Based Electrochemical Biosensing and Emerging Diagnostic Methods

Biosensors, 2023
The utilization of electrochemical detection techniques in paper-based analytical devices (PADs) has revolutionized point-of-care (POC) testing, enabling the precise and discerning measurement of a diverse array of (bio)chemical analytes. The application
Stephen Rathinaraj Benjamin, Fábio de Lima, Valter Aragão do Nascimento, Geanne Matos de Andrade, Reinaldo Barreto Oriá   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

Biosensors, 2023
The need for providing rapid and, possibly, on-the-spot analytical results in the case of intoxication has prompted researchers to develop rapid, sensitive, and cost-effective methods and analytical devices suitable for use in nonspecialized laboratories
Giacomo Musile, Cristian Grazioli, Stefano Fornasaro, Nicolò Dossi, Elio Franco De Palo, Franco Tagliaro, Federica Bortolotti   +6 more
doaj   +1 more source