Results 41 to 50 of about 38,097,238 (288)

Gradient hydrogels based on photo-initiated polymerization-induced self-assembly

Giant
Gradient materials enable performance optimization by adjusting composition or structure across one or more dimensions while minimizing interfacial incompatibility.
Yingchu Zhou, Ziqi Liu, Yi Zeng, Li Luo, Jie Chen, Diyuan Zheng, Zhao Wu, Chao Lang   +7 more
doaj   +1 more source

Paper-Based Device for the Colorimetric Determination of Glucose in Whole-Blood Samples Using a Smartphone

Bioengineering
In many clinical settings, there is a great need for rapid, simple, and reliable diagnostic tools for the detection and quantification of various biomarkers.
Lara B. A. Boga, Katia Gianni, Mariano N. Aleman, Marcos S. Almiron Arroyo, Rossana E. Madrid   +4 more
doaj   +1 more source

Quasi-one-dimensional enaminone-linked covalent organic frameworks for efficient CO₂ photoreduction

Nature Communications
Quasi-one-dimensional covalent organic frameworks have emerged as promising platforms for photochemical energy conversion due to their low density of basal sites, abundant edge sites, and dual-chain-like structure.
Junxian Bai, Yuxin Hu, Fangyuan Si, Yan Li, Guijie Liang, Tingting Hou, Yingwei Li   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Eliciting usage contexts of safety-critical medical devices [PDF]

, 2014
This position paper outlines our approach to improve the usage choice of suitable devices in different health care environments (contexts). Safety-critical medical devices are presumed to have undergone a thorough (user-centred) design process to ...
Reeves, Steve, Jung, Doris, Hinze, Annika, Bowen, Judy, Cunningham, Sally Jo   +4 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Characterization of Reagent Pencils for Deposition of Reagents onto Paper-Based Microfluidic Devices

Micromachines, 2017
Reagent pencils allow for solvent-free deposition of reagents onto paper-based microfluidic devices. The pencils are portable, easy to use, extend the shelf-life of reagents, and offer a platform for customizing diagnostic devices at the point of care ...
Cheyenne H. Liu, Isabelle C. Noxon, Leah E. Cuellar, Amanda L. Thraen, Chad E. Immoos, Andres W. Martinez, Philip J. Costanzo   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reconfigurable meta-devices platform based on stimuli-responsive materials

, 2023
Metasurfaces have been playing their vital role in many fields related to light because they are capable of manipulating its characteristics. Most of the metasurfaces are based on conventional materials so they are unifunctional in the range of interest ...
Ijaz, Sumbel, Mehmood, Muhammad Qasim, Massoud, Yehia Mahmoud, Zubair, Muhammad, Shah, Aqib Raza   +4 more
core   +1 more source