Results 131 to 140 of about 40,906,659 (271)

Biogas production from Opuntia stricta Haw.: microbial diversity and solid load influence on sludge recycle systems

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The search for alternative and sustainable energy sources becomes urgent as energy demand increases and fossil fuels become less available, especially in water‐scarce regions such as the Brazilian semi‐arid region, where current projections of global warming and the expansion of arid and semi‐arid zones point to a future of desertification ...
Wallysson K. P. Barros, Íthalo B. S. de Abreu, Elias G. M. Silva, João V. P. Tavares, Bruna K. O. Silva, Joyce G. W. Siqueira, Rafael B. de Souza, Rômulo S. C. Menezes, Everardo V. S. B. Sampaio, José Antonio Pérez‐Pimienta, Emmanuel D. Dutra   +10 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Transapical valve-in-valve implantation for regurgitant stented aortic bioprostheses

, 2012
Transcatheter aortic valve implantation (TAVI) is rapidly evolving as an alternative treatment option for elderly patients with severe symptomatic aortic stenosis and excessive risk for surgical intervention.
Windecker, Stephan, Carrel, Thierry, Pilgrim, Thomas, Wenaweser, Peter, Kadner, Alexander, Stortecky, Stefan   +5 more
core  

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source

Scale‐Down Platforms for Process‐Oriented Enzyme Screening Using Microfluidics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Enzyme screening platforms are typically evaluated based on their throughput and analytical performance rather than their ability to mimic the conditions encountered at large scale. In bioreactors, enzymes experience gradients in substrate concentration, oxygen availability, pH, temperature, and interfacial exposure, caused by imperfect mixing
Maria I. Rodriguez‐Torres, Elif Erdem, Junhyeong Wang, Ulrich Krühne, Michael Daniele, John M. Woodley   +5 more
wiley   +1 more source

10‐Fold Improvement in Depth Filter Capacity During Integrated Dynamic Bioprocessing (IDB) Purification Through Depth Filter Cycling and Precipitate Control Strategy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT During bsAb1 purification, precipitate was formed during neutralization of the affinity capture product. This precipitate was removed before loading onto the first polishing column in the Integrated Dynamic Bioprocessing (IDB) platform.
David Scherr, Ana Kanazir, Samik Das, Nikunj Sharda, Jan Martinek, David Nellis, Michael Mollet, Jon Coffman   +7 more
wiley   +1 more source

A Modular Micro‐Chemostat System for High‐Throughput Continuous Cultivations

Biotechnology and Bioengineering, EarlyView.
This study presents and demonstrates a modular 12‐channel micro‐chemostat, designed to be used by Genesis, a Robot Scientist developed to automate scientific research in yeast systems biology. The bioreactor performance fulfilled the predefined requirements, and the empirical results from the biological experiments were consistent with the literature ...
Erik Y. Bjurström, Filip Kronström, Ronald S. Reiserer, David K. Schaffer, Dmitry A. Markov, John P. Wikswo, Ross D. King, Ievgeniia A. Tiukova   +7 more
wiley   +1 more source

Stopping, opening, and redirecting fluid flow in paper-based microfluidic devices using thermo-responsive gelatin valves. [PDF]

RSC Adv
Mehrjou A, Safiabadi Tali SH, Ghiasi Tarzi M, Sadiq Z, Jahanshahi-Anbuhi S.   +4 more
europepmc   +1 more source

A Microfluidic TFF Device for Biopharmaceutical Process Development: Scale‐Down Verification of Ultrafiltration and Diafiltration Modes for Monoclonal Antibodies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) is an essential operation in downstream bioprocessing, yet conventional scale‐down models require large material volumes and often fail to capture scale‐relevant hydrodynamics. A microfluidic TFF (µTFF) platform was developed that preserves wall shear rate and transmembrane pressure, enabling low‐volume ...
Nusrat Jahan, Nicolas Szita, Spyridon Konstantinidis, Marco P. C. Marques   +3 more
wiley   +1 more source

Research on digital valve-controlled hydraulic system for active radial control of wheelsets

机车电传动
This paper addresses the issue of excessive heat generation in active radial hydraulic servo control systems by proposing an active radial digital valve-controlled hydraulic system for wheelsets based on the pulse-code modulation (PCM) technique.
NI Wenbo, LIU Shuwei, WANG Xuemei
doaj