Results 41 to 50 of about 5,224,362 (260)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Recent developments in microfluidic paper-, cloth-, and thread-based electrochemical devices for analytical chemistry

open access: yesReviews in Analytical Chemistry, 2017
The attractive structural and mechanical properties of cellulose substrates (paper, cloth, and thread), including passive fluid transport, biocompatibility, durability, and flexibility, have attracted researchers in the past few decades to explore them ...
Malon Radha S.P.   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Characteristics of Local Anisotropy Fields of Paper Structure and Deformation Properties

open access: yesЛесной журнал
The results of a comparative assessment of the physical and mechanical characteristics of moisture-resistant packaging paper made of bleached softwood and hardwood pulp are presented. Non-destructive and destructive methods have been used to measure 60 g/
Mariya M. Lysachenkova   +2 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Spectres of Paper: Writing, Digitization, and the End(s) of the Book [PDF]

open access: yesAvant, 2017
This paper has been inspired by Jacques Derrida’s statement revealing that his philosophical writings were mostly devoted to paper. “I have the impression,” he said, “(the impression!—what a word, already) that I have never had any other subject ...
Tadeusz Rachwał
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Development of Paper Utilizing Miscanthus Pulp Combined with Waste Paper for the Production of Packaging

open access: yesApplied Sciences
Much focus is being dedicated to the development of innovative technologies for producing biodegradable polymers from plant biomass. It is proposed that annual and perennial herbaceous plants, such as miscanthus, be used as promising sources of cellulose.
Yulia Sevastyanova   +13 more
doaj   +1 more source

¿Qué es una ocurrencia? Sobre humanidades y ciencias

open access: yesSíntesis. Revista de Filosofía, 2020
En primer término, se aborda la relación asimétrica de humanidades y ciencias en las instituciones contemporáneas de conocimiento sugiriendo la inconveniencia de acentuar la diferencia entre unas y otras, en la medida en que ambos órdenes epistémicos ...
Pablo Oyarzún
doaj   +1 more source

Micro‐mechanism study on synergistic degradation of the oil‐paper insulation with dibenzyl disulfide, hexadecyl mercaptan and benzothiophene

open access: yesHigh Voltage, 2021
In recent years, there have been many cases of transformer failures caused by corrosive sulfides. At present, research mainly focuses on the single sulfide dibenzyl disulphide, but few research on multiple sulphur or the oil‐paper hybrid insulation.
Haoxi Cong   +4 more
doaj   +1 more source

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