Results 21 to 30 of about 359,301 (251)

Development of an Analytical Procedure for the Quantitative Determination of Choline in Ear Drops Based on Viscum album Leaf Soft Extract

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. A new ear drop composition based on European mistletoe (Viscum album L.) leaf soft extract was developed to meet the demand for cerumenolytic ear drops.
S. L. Adzhiakhmetova, A. E. Pozdnyakova
doaj   +1 more source

Microfluidic Free‐Flow Paper Electrochromatography for Continuous Separation of Glycans

ChemElectroChem, 2022
Microfluidic free‐flow electrophoresis (μ‐FFE) is widely used for continuous separation of charged analytes. However, μ‐FFE is limited in the separation of analytes with the same electrophoretic mobility.
Yingchao Liu, Yuanyu Huang, Mengxi Wu, Siyuan Kong, Dr. Weiqian Cao, Shunxiang Li, Guoquan Yan, Prof. Baohong Liu, Prof. Pengyuan Yang, Dr. Quanqing Zhang, Prof. Liang Qiao, Prof. Huali Shen   +11 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An Electrochemical Gas Biosensor Based on Enzymes Immobilized on Chromatography Paper for Ethanol Vapor Detection

Sensors, 2017
This paper presents a novel method of fabricating an enzymatic biosensor for breath analysis using chromatography paper as enzyme supporting layer and a liquid phase layer on top of screen printed carbon electrodes.
Tatsumi Kuretake, Shogo Kawahara, Masanobu Motooka, Shigeyasu Uno   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Fuel Dilution in Hybrid Engine Oils: Correlation Between Viscosity Loss and FTIR Spectral Shifts in Modern Combustion Systems

Energies
This study investigates fuel-induced oil dilution in hybrid powertrains using a combined assessment of kinematic viscosity and FTIR differential spectroscopy.
Artur Wolak, Grzegorz Zając
doaj   +1 more source

Determination of cocaine in brazilian paper currency by capillary gas chromatography/mass spectrometry

Química Nova, 2007
The presence of illicit drugs such as cocaine and marijuana in US paper currency is very well demonstrated. However, there is no published study describing the presence of cocaine and/or other illicit drugs in Brazilian paper currency.
Enrico Di Donato, Carmen Cinira Santos Martin, Bruno Spinosa De Martinis   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source