Results 61 to 70 of about 5,770,642 (266)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Determining the Pulping Conditions and Properties of Unbleached Pulp from Uruguayan Pinus Taeda
IngenieríaContext: In Uruguay, numerous Pinus taeda plantations are at final-turn age, but they still do not have commercial destination and are exported as green-wood logs.
Viviana Palombo +2 more
doaj +1 more source
Thermo-Mechanical Properties of Polypropylene Composites Filled with Recycled Office Waste Paper
Journal of Natural Fibers, 2022 The high production of paper, followed by a more significant concern with environmental and economic issues, has led to greater relevance to paper recycling and its raw uses as composite filler.
Marina Gil Almeida Cioffi +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Legibility of Sans-Serif Typeface on Different Paper Grades Made from Invasive Alien Plant Species
Applied SciencesInvasive alien plant species (IAPS) may cause threats to native biodiversity in ecosystems. Researchers have been investigating all the possible ways that they can be used effectively for other purposes.
Klementina Možina +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
BioResources, 2016 Corn stalk, an agricultural waste, was valorized by the production of cellulose nanofibers (CNF), which were tested for improving recycled paper properties. CNF from eucalyptus kraft pulp (E-CNF) was used as a reference. Addition of 0.5% wt. CNF produced
Ana Balea +6 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Preparation of Paper Strengthening Agent by Esterification of Cellulosic Fines
BioResources, 2016 Paper strengthening agents play an important role in the papermaking industry with the increase of secondary fiber applications. The objective of this study was to create a dry-strength agent by esterification.
Lin-Yu Yan +2 more
doaj +1 more source