Results 151 to 160 of about 25,243 (199)
Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting +5 more
wiley +1 more source
T cell receptor β‐chain repertoire analysis reveals the association between neoantigens and tumour‐infiltrating lymphocytes in multifocal papillary thyroid carcinoma [PDF]
Zheming Lu +4 more
openalex +1 more source
ZNF282 Promotes Colorectal Cancer Progression Possibly via E2F1 Activation
ZNF282 is a zinc finger protein overexpressed in colorectal cancer that facilitates tumor progression by promoting cell cycle progression via E2F1 activation. Our study demonstrates that ZNF282 expression is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target. ABSTRACT Colorectal cancer (CRC) is a leading
Tadashi Abe +23 more
wiley +1 more source
In this study, we identified a novel biomarker, carbonic anhydrase 12 (CA12), to better distinguish high‐risk follicular thyroid carcinoma (FTC). High CA12 expression is associated with poor prognosis and CA12 promotes tumor cell growth and invasion. This study suggests that CA12 is not only an independent predictor of disease‐free survival but also a ...
Masashi Tanida +14 more
wiley +1 more source
Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG‐TOP2 Study
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Kayoko Tao +38 more
wiley +1 more source
Independent Clonal Origins of Distinct Tumor Foci in Multifocal Papillary Thyroid Carcinoma [PDF]
openalex +1 more source
Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing
ABSTRACT Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling and malignancy aggressiveness. Design We conducted a retrospective multicenter study involving patients with
Idit Tessler +7 more
wiley +1 more source

