Results 221 to 230 of about 848,603 (303)

Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion

open access: yesHistopathology, EarlyView.
Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang   +4 more
wiley   +1 more source

Encapsulated papillary carcinoma: Diagnosis, treatment, and prognostic outcomes: A report of 2 case report. [PDF]

open access: yesMedicine (Baltimore)
Al-Jawad M   +6 more
europepmc   +1 more source

Long‐term outcome of high‐grade encapsulated papillary carcinoma of the breast: implications for staging and management

open access: yesHistopathology, EarlyView.
In the original study by Rakha et al., the authors proposed that high‐grade EPC should be considered within an invasive framework regardless of hormone receptor status. In the present study, we adopted a more selective definition of EPC‐A, restricted to tumours showing more adverse features, including high‐grade morphology together with triple‐negative
Milena Stevanovic   +9 more
wiley   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

open access: yesHistopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Novel and emerging skin carcinomas and adnexal tumours

open access: yesHistopathology, EarlyView.
The present review aims to provide an overview of the main emerging skin epithelial tumours, with particular emphasis on salivary gland analogue sweat gland tumours and poorly differentiated carcinomas. Epidermal and adnexal tumours of the skin constitute a complex and heterogeneous group of neoplasms, with distinct morphology and behaviour.
Thibault Kervarrec   +2 more
wiley   +1 more source

HMGA2 is a highly sensitive marker for DICER1‐related tumours

open access: yesHistopathology, EarlyView.
Aims DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1‐related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent‐onset tumours.
Paul S. Thorner   +5 more
wiley   +1 more source

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