Results 61 to 70 of about 11,249 (259)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Morphological and attachment site variations of maxillary labial frenulum [PDF]

Stomatološki glasnik Srbije, 2019
Introduction Maxillary labial frenulum (MLF) is a mucous membrane fold that shows diversity in morphology, position and clinical significance throughout life. The aim of the study was to evaluate different morphological variations and MLF attachment site
Lečić Jelena, Janković Svjetlana, Davidović Bojana, Cicmil Ana, Govedarica Olivera, Cicmil Smiljka   +5 more
doaj  

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Introduction to skin aging [PDF]

, 2016
YesCutaneous science has seen considerable development in the last 25 years, in part due to the -Omics revolution, and the appreciation that this organ is hardwired into the body’s key neuroimmuno- endocrine axes.
Affinito, Ashcroft, Batisse, Baumann, Ben-Yehuda, Bernstein, Bernstein, Bhushan, Bolognia, Bosset, Bosset, Branchet, Braverman, Brincat, Brincat, Brincat, Brincat, Calleja-Agius, Callens, Cerimele, Choi, Christensen, Christophers, Chuong, Commo, Contet-Audonneau, Dunn, Ellis, Ernster, Escoffier, Farage, Farage, Fenske, Garn, Ghadially, Gilchrest, Gilchrest, Gilchrest, Gniadecka, Gniadecka, Gniadecka, Gniadecka, Goodson, Graham-Brown, Grove, Grove, Grove, Gunn, Hachem, Hall, Harvell, Hay, Helmdach, Hurley, Kadono, Kadunce, Karnik, Kauser, Keogh, Kligman, Kligman, Kochevar, Kosmadaki, Landau, Lavker, Lavker, Leyden, Li, Lovell, Makinodan, Makrantonaki, Montagna, Nakamura, Nishimura, Nordlund, Oberste-Lehn, Oikarinen, Olsen, Orentreich, Panhard, Parsons, Plewig, Plowden, Pochi, Rees, Richard, Rittié, Ritz-Timme, Robert, Robinson, Saint Leger, Sandby-Moller, Sator, Scharffetter-Kochanek, Schreml, Seite, Seité, Shetage, Shuster, Silver, Smith, Thiers, Thornton, Tobin, Tobin, Tobin, Toyoda, Tsuji, Tur, Uitto, Unver, Varani, Waldorf, Waller, Watson, Watson, Watson, Whiting, Winkelmann, Yaar, Yin, Yin, Young   +122 more
core   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Clinical Features of Impacted Common Bile Duct Stones at Duodenal Papilla

The Korean Journal of Gastroenterology
Background/Aims: Urgent endoscopic removal is required for gallstones impacted at the duodenal papilla. This study compared the clinical features of impacted papillary stones (IPS) with those of common bile duct stones without impaction.
Jae Min Lee, Sang Hoon Lee, Ji Hyun Kim, Tae Suk Kim, Sung Hoon Chang, San Ha Kim, Jung Ho Lee, Chang Don Kang, Jin Myung Park   +8 more
doaj   +1 more source

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]

, 2018
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Grisanti, Laurel A., Koch, Walter J., Thomas, Toby P., Tilley, Douglas G.   +7 more
core   +1 more source

Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation

Advanced Science, EarlyView.
The lamina joint determines leaf angle and plant architecture. Xu et al. establish a live‐imaging system for the rice lamina joint and reveal that asymmetric epidermal cell elongation and division between the lateral and medial edges drive leaf angle formation.
Yiru Xu, Heng Zhou, Xiaojiang Wu, Wuyu Cui, Shouling Xu, Xi He, Dan Xiang, Ming Zhou, Xiuqin Rao, Lilan Hong   +9 more
wiley   +1 more source

Ventricular Septal Defect and Mitral Regurgitation Due to Penetrating Cardiac Trauma; a Case Report and Review of Literature

Archives of Academic Emergency Medicine
Penetrating cardiac trauma is a fatal condition and can result in the injury of various parts of the heart. Ventricular Septal Defect (VSD) following these traumas occurs only in 1-5% of cases.
Hojjat Mortezaeian , Avisa Tabib, Hamidreza Pouraliakbar, Mohsen Anafje, Pouya Ebrahimi, Parnian Soltani   +5 more
doaj   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source